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Dr. Frederick H. Leibach

Medical College of Georgia
Medicine
Biochemistry and Molecular Biology
Professor     Appointed: 1991

Medical College of Georgia
Medicine
Biochemistry and Molecular Biology
Chairman     Appointed: 1991
Mailing Address
Department of Biochemistry and Molecular Biology
Medical College of Georgia
1120 15th St.
Augusta, Georgia 30912-2100
United States
Contact Information
Phone: (706) 721-7661
Fax: (706) 721-6608
FLEIBACH@mail.mcg.edu
Qualifications
B.S., S.W. Missouri State University, Chemistry, 1959
Ph.D., Emory University, Biochemistry, 1964
Expertise and Research Interests
Enzyme interactions in metabolic control. The relationship between regulation of metabolic processes and transport systems in kidney, placenta, intestine, and eye. Isolation, reconstitution and regulation of membrane transport proteins. Regulation of the activity of transport proteins by nutrients and second messengers. Cloning and sequencing of genes coding for transport proteins.
Keywords
COS Keywords: Biochemistry; Biochemistry, Proteins; Enzymes; Molecular Biology; Proteins and Macromolecules
Additional Terms: Biochemistry; Molecular Biology; Transport Proteins
Languages
Reading, Writing, Speaking:
German: (Fluent, Fluent, Fluent)
Memberships
American Association for the Advancement of Science
American Chemical Society
American Physiological Society
American Society for Biochemistry and Molecular Biology
American Society for Parenteral and Enteral Nutrition
American Society of Nephrology
Sigma Xi, The Scientific Research Society
Previous Positions
1979-1991, Professor, Medical College of Georgia, Medicine, Cell and Molecular Biology
1973-1979, Associate Professor, Medical College of Georgia, Medicine, Cell and Molecular Biology
1967-1973, Assistant Professor, Medical College of Georgia, Medicine, Cell and Molecular Biology
1964-1967, Postdoctoral Research Fellow of the National Academy of Sciences, NASA Ames Research Center, California
Professor (Joint Appointment), Medical College of Georgia, Medicine, Physiology and Endocrinology
Publications
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V, beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter., Journal of Biological Chemistry, 275(3):1699-707, 21 2000 Abstract
  • Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD, Human Na\(+\)-dependent vitamin C transporter 1 \(hSVCT1\): primary structure, functional characteristics and evidence for a non-functional splice variant., Biochimica et Biophysica Acta, 1461(1):1-9, 9 Nov 1999 Abstract
  • Huang W, Shaikh SN, Ganapathy ME, Hopfer U, Leibach FH, Carter AL, Ganapathy V, Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells., Biochemical Pharmacology, 58(8):1361-70, 15 Oct 1999 Abstract
  • Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD, Human placental sodium-dependent vitamin C transporter \(SVCT2\): molecular cloning and transport function., Biochemical and Biophysical Research Communications, 262(3):762-8, 7 Sep 1999 Abstract
  • Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V, Functional characteristics and tissue distribution pattern of organic cation transporter 2 \(OCTN2\), an organic cation/carnitine transporter., Journal of Pharmacology and Experimental Therapeutics, 290(3):1482-92, September 1999 Abstract
  • Fujita T, Majikawa Y, Umehisa S, Okada N, Yamamoto A, Ganapathy V, Leibach FH, sigma Receptor ligand-induced up-regulation of the H(+\)/peptide transporter PEPT1 in the human intestinal cell line Caco-2., Biochemical and Biophysical Research Communications, 261(2):242-6, 2 Aug 1999 Abstract
  • Kenney SP, Kekuda R, Prasad PD, Leibach FH, Devoe LD, Ganapathy V, Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta., American Journal of Obstetrics and Gynecology, 181(2):491-7, August 1999 Abstract
  • Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V, Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter., Archives of Biochemistry and Biophysics, 366(1):95-106, 1 Jun 1999 Abstract
  • Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD, Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization., Journal of Biological Chemistry, 274(21):14875-83, 21 May 1999 Abstract
  • Fei YJ, Nara E, Liu JC, Boyd CA, Ganapathy V, Leibach FH, Preferential recognition of zwitterionic dipeptides as transportable substrates by the high-affinity peptide transporter PEPT2., Biochimica et Biophysica Acta, 1418(2):344-51, 12 May 1999 Abstract
  • Wu X, Fei YJ, Huang W, Chancy C, Leibach FH, Ganapathy V, Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter., Biochimica et Biophysica Acta, 1418(1):239-44, 14 Apr 1999 Abstract
  • Ganapathy ME, Prasad PD, Huang W, Seth P, Leibach FH, Ganapathy V, Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line., Journal of Pharmacology and Experimental Therapeutics, 289(1):251-60, April 1999 Abstract
  • Prasad PD, Wang H, Huang W, Kekuda R, Rajan DP, Leibach FH, Ganapathy V, Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function., Biochemical and Biophysical Research Communications, 255(2):283-8, 16 Feb 1999 Abstract
  • Kekuda R, Wang H, Huang W, Pajor AM, Leibach FH, Devoe LD, Prasad PD, Ganapathy V, Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter., Journal of Biological Chemistry, 274(6):3422-9, 5 Feb 1999 Abstract
  • Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V, Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter \(uptake2\) and evidence for the expression of the transporter in the brain., Journal of Biological Chemistry, 273(49):32776-86, 4 Dec 1998 Abstract
  • Wang H, Fei YJ, Ganapathy V, Leibach FH, Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain., American Journal of Physiology, 275(4 Pt 1):C967-75, October 1998 Abstract
  • Fei Y J, Fujita T, Lapp D F, Ganapathy V, Leibach F H, Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression., Biochemical Journal, 332 ( Pt 2), 565-72, 1 Jun 1998 Abstract
  • Wu X, Prasad PD, Leibach FH, Ganapathy V, cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family., Biochemical and Biophysical Research Communications, 246(3):589-95, 29 1998 Abstract
  • Ganapathy M E, Huang W, Wang H, Ganapathy V, Leibach F H, Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2., Biochemical and Biophysical Research Communications, 246(2):470-5, 19 May 1998 Abstract
  • Fei YJ, Liu JC, Fujita T, Liang R, Ganapathy V, Leibach FH, Identification of a potential substrate binding domain in the mammalian peptide transporters PEPT1 and PEPT2 using PEPT1-PEPT2 and PEPT2-PEPT1 chimeras., Biochemical and Biophysical Research Communications, 246(1):39-44, 8 1998 Abstract
  • Torres-Zamorano V, Leibach F H, Ganapathy V, Sodium-dependent homo- and hetero-exchange of neutral amino acids mediated by the amino acid transporter ATB degree., Biochemical and Biophysical Research Communications, 245(3):824-9, 28 Apr 1998 Abstract
  • Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V, Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate., Journal of Biological Chemistry, 273(13):7501-6, 27 1998 Abstract
  • Prasad PD, Huang W, Wang H, Leibach FH, Ganapathy V, Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line., Biochimica et Biophysica Acta, 1369(1):141-51, 2 1998 Abstract
  • YJ Fei, V Ganapathy, and FH Leibach, Molecular and structural features of the proton-coupled oligopeptide transporter superfamily, Progress in Nucleic Acid Research and Molecular Biology, 58, 239-261, 1998
  • X Wu, PD Prasad, FH Leibach, and V Ganapathy, cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family, Biochemical and Biophysical Research Communications, 246, 589-595, 1998
  • ME Ganapathy, W Huang, H Wang, V Ganapathy, and FH Leibach, A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2, Biochemical and Biophysical Research Communications, 246, 470-475, 1998
  • YJ Fei, JC Liu, T Fujita, R Liang, V Ganapathy and FH Leibach, Identification of a potential substrate binding domain in the mammalian peptide transporters PEPT1 and PEPT2 using PEPT1-PEPT2 and PEPT2-PEPT1 chimeras, Biochemical and Biophysical Research Communications, 246, 39-44, 1998
  • V Torres-Zamorano, FH Leibach, and V Ganapathy, Sodium-dependent homo- and hetero-exchange of neutral amino acids mediated by the amino acid transporter ATBo, Biochemical and Biophysical Research Communications, 245, 824-829, 1998
  • R Kekuda, PD Prasad, X Wu, H Wang, YJ Fei, FH Leibach, and V Ganapathy, Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta, Journal of Biological Chemistry, 273, 15971-15979, 1998
  • PD Prasad, H Wang, R Kekuda, T Fujita, YJ Fei, LD Devoe, FH Leibach, and V Ganapathy, Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate, Journal of Biological Chemistry, 273, 7501-7506, 1998
  • PD Prasad, W Huang, H Wang, FH Leibach, and V Ganapathy, Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line, Biochimica et Biophysica Acta, 1369, 141-151, 1998
  • V Ganapathy, PD Prasad, and FH Leibach, Use of human placenta in studies of monoamine transporters, Methods in Enzymology, in press, , 1998
  • P Seth, YJ Fei, HW Li, W Huang, FH Leibach, and V Ganapathy, Cloning and functional characterization of a sigma receptor from rat brain, Journal of Neurochemistry, 70, 922-931, 1998
  • PD Prasad, HW Li, YJ Fei, ME Ganapathy, T Fujita, LH Plumley, TL Yang-Feng, FH Leibach, and V Ganapathy, Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene, Journal of Neurochemistry, 70, 443-451, 1998
  • H Wang, YJ Fei, V Ganapathy, and FH Leibach, Electrophysiologic characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain, American Journal of Physiology, in press, , 1998
  • V Borner, YJ Fei, B Hartrodt, V Ganapathy, FH Leibach, K Neubert, and M Brandsch, Transport of amino acid aryl amides by the intestinal H+/peptide cotransport system, PEPT1, European Journal of Biochemistry, 255, 698-702, 1998
  • YJ Fei, T Fujita, DF Lapp, V Ganapathy, and FH Leibach, Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression, Biochemical Journal, 332, 565-572, 1998
  • Seth P, Leibach FH, Ganapathy V, Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor., Biochemical and Biophysical Research Communications, 241(2):535-40, 18 Dec 1997 Abstract
  • Bockman DE, Ganapathy V, Oblak TG, Leibach FH, Localization of peptide transporter in nuclei and lysosomes of the pancreas., International Journal of Pancreatology, 22(3):221-5, December 1997 Abstract
  • Huang W, Prasad P D, Kekuda R, Leibach F H, Ganapathy V, Characterization of N5-methyltetrahydrofolate uptake in cultured human retinal pigment epithelial cells., Investigative Ophthalmology and Visual Science, 38(8):1578-87, July 1997 Abstract
  • Kekuda R, Torres-Zamorano V, Fei Y J, Prasad P D, Li H W, Mader L D, Leibach F H, Ganapathy V, Molecular and functional characterization of intestinal Na(+)-dependent neutral amino acid transporter B0., American Journal of Physiology, 272(6 Pt 1):G1463-72, June 1997 Abstract
  • Torres-Zamorano v, Kekuda R, Leibach F H, Ganapathy V, Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR., Biochimica Et Biophysica Acta, 1356(3):258-70, 27 May 1997 Abstract
  • Kekuda R, Torres-Zamorano V, Leibach F H, Ganapathy V, Human serotonin transporter: regulation by the neuroprotective agent aurintricarboxylic acid and by epidermal growth factor., Journal of Neurochemistry, 68(4):1443-50, April 1997 Abstract
  • Brandsch M, Brandsch C, Ganapathy ME, Chew CS, Ganapathy V, Leibach FH, Influence of proton and essential histidyl residues on the transport kinetics of the H+/peptide cotransport systems in intestine \(PEPT 1\) and kidney \(PEPT 2\)., Biochimica et Biophysica Acta, 1324(2):251-62, 13 1997 Abstract
  • Fei Y J, Liu W, Prasad P D, Kekuda R, Oblak T G, Ganapathy V, Leibach F H, Identification of the histidyl residue obligatory for the catalytic activity of the human H+/peptide cotransporters PEPT1 and PEPT2., Biochemistry, 36(2):452-60, 14 Jan 1997 Abstract
  • PD Prasad, V Torres-Zamorano, R Kekuda, FH Leibach, and V Ganapathy, Functional link between tyrosine phosphorylation and human serotonin transporter gene expression, European Journal of Pharmacology, 325, 85-92, 1997
  • R Kekuda, V Torres-Zamorano, YJ Fei, PD Prasad, HW Li, LD Mader, FH Leibach, and V Ganapathy, Molecular and functional characterization of the intestinal sodium-dependent neutral amino acid transporter Bo, American Journal of Physiology, 272, G1463-G1472, 1997
  • W Huang, PD Prasad, R Kekuda, FH Leibach, and V Ganapathy, Characterization of N5-methyltetrahydrofolate uptake in human retinal pigment epithelial cells, Investigative Ophthalmology and Visual Science, 38, 1578-1587, 1997
  • PD Prasad, S Ramamoorthy, FH Leibach, and V Ganapathy, Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate in human placental choriocarcinoma cells, Placenta, 18, 527-533, 1997
  • PD Prasad, FH Leibach, and V Ganapathy, Transplacental transport of water-soluble vitamins, Trophoblast Research, 11, 243-257, 1997
  • DE Bockman, V Ganapathy, TG Oblak, and FH Leibach, Localization of peptide transporter in nuclei and lysosomes of the pancreas, International Journal of Pancreatology, 22, 221-225, 1997
  • P Seth, FH Leibach, and V Ganapathy, Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor, Biochemical and Biophysical Research Communications, 241, 535-540, 1997
  • V Torres-Zamorano, R Kekuda, FH Leibach, and V Ganapathy, Tyrosine phosphorylation- and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transproter Bo in the human placental choriocarcinoma cell line JAR, Biochimica et Biophysica Acta, 1356, 258-270, 1997
  • ME Ganapathy, PD Prasad, B Mackenzie, V Ganapathy, and FH Leibach, Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2, Biochimica et Biophysica Acta, 1324, 296-308, 1997
  • R Kekuda, V Torres-Zamorano, FH Leibach, and V Ganapathy, Human serotonin transporter: Regulation by the neuroprotective agent aurintricarboxylic acid and by epidermal growth factor, Journal of Neurochemistry, 68, 1443-1450, 1997
  • M Brandsch, C Brandsch, ME Ganapathy, CS Chew, V Ganapathy, and FH Leibach, Influence of proton and essential histidyl residues on the transport kinetics of the H+/peptide cotransport systems in intestine (PEPT 1) and kidney (PEPT 2), Biochimica et Biophysica Acta, 1324, 251-262, 1997
  • YJ Fei, W Liu, PD Prasad, R Kekuda, TG Oblak, V Ganapathy, and FH Leibach, Identification of the histidyl residue obligatory for the cartalytic activity of the human H+/peptide cotransporters PEPT 1 and PEPT 2, Biochemistry, 36, 452-460, 1997
  • Mackenzie B, Fei Y J, Ganapathy V, Leibach F H, The human intestinal H+/oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical electrogenic properties., Biochimica Et Biophysica Acta, 1284(2):125-8, 23 Oct 1996 Abstract
  • Kekuda R, Prasad P D, Fei Y J, Torres-Zamorano V, Sinha S, Yang-Feng T L, Leibach F H, Ganapathy V, Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line., Journal of Biological Chemistry, 271(31):18657-61, 2 Aug 1996 Abstract
  • Roque A S, Prasad P D, Bhatia J S, Leibach F H, Ganapathy V, Sodium-dependent high-affinity binding of carnitine to human placental brush border membranes., Biochimica Et Biophysica Acta, 1282(2):274-82, 25 Jul 1996 Abstract
  • Mackenzie B, Loo D D, Fei Y, Liu W J, Ganapathy V, Leibach F H, Wright E M, Mechanisms of the human intestinal H+-coupled oligopeptide transporter hPEPT1., Journal of Biological Chemistry, 271(10):5430-7, 8 Mar 1996 Abstract
  • R Kekuda, PD Prasad, YJ Fei, FH Leibach, and V Ganapathy, Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1), Biochemical and Biophysical Research Communications, 229, 553-558, 1996
  • B Mackenzie, YJ Fei, V Ganapathy, and FH Leibach, The human intestinal H+/oligopeptide cotransporter hPEPT 1 transports differently-charged dipeptides with identical electrogenic properties, Biochimica et Biophysica Acta, 1284, 125-128, 1996
  • PD Prasad, W Huang, S Ramamoorthy, AL Carter, FH Leibach, and V Ganapathy, Sodium-dependent carnitine transport in human placental choriocarcinoma cells, Biochimica et Biophysica Acta, 1284, 109-117, 1996
  • V Ganapathy and FH Leibach, Peptide transporters, Current Opinion in Nephrology and Hypertension, 5, 395-400, 1996
  • R Kekuda, PD Prasad, YJ Fei, VT Zamorano, S Sinka, TL Yang-Feng, FH Leibach, and V Ganapathy, Cloning of a sodium dependent, broad-scope, neural amino acid transporter Bo from a human placental choriocarcinoma cell line, Journal of Biological Chemistry, 271, 18657-18661, 1996
  • AS Roque, PD Prasad, JS Bhatia, FH Leibach, and V Ganapathy, Sodium dependent high affinity binding of carnitine to human placental brush border membranes, Biochimica et Biophysica Acta, 1282, 274-282, 1996
  • FH Leibach and V Ganapathy, Peptide transporters in the intestine and kidney, Annual Review of Nutrition, 16, 99-199, 1996
  • B Mackenzie, DDF Loo, YJ Fei, W Liu, V Ganapathy, and FH Leibach, Mechanism of the human intestinal H+-coupled oligopeptide transporter hPEPT 1, Journal of Biological Chemistry, 218, 5430-5437, 1996
  • U Muller, M Brandsch, PD Prasad, YJ Fei, V Ganapathy, and FH Leibach, Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP, Biochemical and Biophysical Research Communications, 218, 461-465, 1996
  • PD Prasad, B Hoffman, A Moe, CH Smith, FH Leibach, V Ganapathy, Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells, Placenta, 17, 201-207, 1996
  • Leibach F H, Ganapathy V, Peptide transporters in the intestine and the kidney., Annual Review of Nutrition, 16, 99-119, 1996 Abstract
  • Ramamoorthy J D, Ramamoorthy S, Leibach F H, Ganapathy V, Human placental monoamine transporters as targets for amphetamines., American Journal of Obstetrics and Gynecology, 173(6):1782-7, December 1995 Abstract
  • Ramamoorthy S, Liu W, Ma Y Y, Yang-Feng T L, Ganapathy V, Leibach F H, Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization., Biochimica Et Biophysica Acta, 1240(1):1-4, 22 Nov 1995 Abstract
  • Ramamoorthy S, Ramamoorthy J D, Prasad P D, Bhat G K, Mahesh V B, Leibach F H, Ganapathy V, Regulation of the human serotonin transporter by interleukin-1 beta., Biochemical and Biophysical Research Communications, 216(2):560-7, 13 Nov 1995 Abstract
  • Brandsch M, Brandsch C, Prasad P D, Ganapathy V, Hopfer U, Leibach F H, Identification of a renal cell line that constitutively expresses the kidney-specific high-affinity H+/peptide cotransporter., Faseb Journal, 9(14):1489-96, November 1995 Abstract
  • Ganapathy M E, Brandsch M, Prasad P D, Ganapathy V, Leibach F H, Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2., Journal of Biological Chemistry, 270(43):25672-7, 27 Oct 1995 Abstract
  • Ganapathy V, Ramamoorthy J D, Del Monte M A, Leibach F H, Ramamoorthy S, Cyclic AMP-dependent up-regulation of the taurine transporter in a human retinal pigment epithelial cell line., Current Eye Research, 14(9):843-50, September 1995 Abstract
  • Ramamoorthy J D, Ramamoorthy S, Papapetropoulos A, Catravas J D, Leibach F H, Ganapathy V, Cyclic AMP-independent up-regulation of the human serotonin transporter by staurosporine in choriocarcinoma cells., Journal of Biological Chemistry, 270(29):17189-95, 21 Jul 1995 Abstract
  • Fei Y J, Prasad P D, Leibach F H, Ganapathy V, The amino acid transport system y+L induced in Xenopus laevis oocytes by human choriocarcinoma cell (JAR) mRNA is functionally related to the heavy chain of the 4F2 cell surface antigen., Biochemistry, 34(27):8744-51, 11 Jul 1995 Abstract
  • Brandsch M, Ramamoorthy S, Marczin N, Catravas J D, Leibach J W, Ganapathy V, Leibach F H, Regulation of taurine transport by Escherichia coli heat-stable enterotoxin and guanylin in human intestinal cell lines., Journal of Clinical Investigation, 96(1):361-9, July 1995 Abstract
  • Yang-Feng T L, Ma Y Y, Liang R, Prasad P D, Leibach F H, Ganapathy V, Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization., Biochemical and Biophysical Research Communications, 210(3):874-9, 25 May 1995 Abstract
  • Liu W, Liang R, Ramamoorthy S, Fei Y J, Ganapathy M E, Hediger M A, Ganapathy V, Leibach F H, Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney., Biochimica Et Biophysica Acta, 1235(2):461-6, 4 May 1995 Abstract
  • Jayanthi L D, Ramamoorthy S, Mahesh V B, Leibach F H, Ganapathy V, Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR)., Biochimica Et Biophysica Acta, 1235(2):351-60, 4 May 1995 Abstract
  • Liang R, Fei Y J, Prasad P D, Ramamoorthy S, Han H, Yang-Feng T L, Hediger M A, Ganapathy V, Leibach F H, Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization., Journal of Biological Chemistry, 270(12):6456-63, 24 Mar 1995 Abstract
  • Brandsch M, Ganapathy V, Leibach F H, H(+)-peptide cotransport in Madin-Darby canine kidney cells: expression and calmodulin-dependent regulation., American Journal of Physiology, 268(3 Pt 2):F391-7, March 1995 Abstract
  • Ramamoorthy J D, Ramamoorthy S, Mahesh V B, Leibach F H, Ganapathy V, Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells., Endocrinology, 136(3):924-32, March 1995 Abstract
  • Prasad P D, Ramamoorthy S, Leibach F H, Ganapathy V, Molecular cloning of the human placental folate transporter., Biochemical and Biophysical Research Communications, 206(2):681-7, 17 Jan 1995 Abstract
  • Ganapathy V, Leibach F H, Human placenta: a direct target for cocaine action., Placenta, 15(8):785-95, December 1994 Abstract
  • Liu W, Leibach F H, Ganapathy V, Characterization of the glycine transport system GLYT 1 in human placental choriocarcinoma cells (JAR)., Biochimica Et Biophysica Acta, 1194(1):176-84, 24 Aug 1994 Abstract
  • Prasad P D, Ramamoorthy S, Moe A J, Smith C H, Leibach F H, Ganapathy V, Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells., Biochimica Et Biophysica Acta, 1223(1):71-5, 11 Aug 1994 Abstract
  • Ramamoorthy S, Del Monte M A, Leibach F H, Ganapathy V, Molecular identity and calmodulin-mediated regulation of the taurine transporter in a human retinal pigment epithelial cell line., Current Eye Research, 13(7):523-9, July 1994 Abstract
  • Prasad P D, Mahesh V B, Leibach F H, Ganapathy V, Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells., Biochimica Et Biophysica Acta, 1222(2):309-14, 30 Jun 1994 Abstract
  • Brandsch M, Leibach F H, Mahesh V B, Ganapathy V, Calmodulin-dependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells., Biochimica Et Biophysica Acta, 1192(2):177-84, 22 Jun 1994 Abstract
  • Ramamoorthy S, Leibach F H, Mahesh V B, Han H, Yang-Feng T, Blakely R D, Ganapathy V, Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta., Biochemical Journal, 300 ( Pt 3), 893-900, 15 Jun 1994 Abstract
  • Jayanthi L D, Ramamoorthy S, Mahesh V B, Leibach F H, Ganapathy V, Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells., Journal of Biological Chemistry, 269(20):14424-9, 20 May 1994 Abstract
  • Fei Y J, Kanai Y, Nussberger S, Ganapathy V, Leibach F H, Romero M F, Singh S K, Boron W F, Hediger M A, Expression cloning of a mammalian proton-coupled oligopeptide transporter., Nature, 368(6471):563-6, 7 Apr 1994 Abstract
  • Prasad P D, Leibach F H, Mahesh V B, Ganapathy V, Human placenta as a target organ for cocaine action: interaction of cocaine with the placental serotonin transporter., Placenta, 15(3):267-78, April 1994 Abstract
  • Brandsch M, Miyamoto Y, Ganapathy V, Leibach F H, Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line., Biochemical Journal, 299 ( Pt 1), 253-60, 1 Apr 1994 Abstract
  • Prasad P D, Leibach F H, Mahesh V B, Ganapathy V, Relationship between thyroid hormone transport and neutral amino acid transport in JAR human choriocarcinoma cells., Endocrinology, 134(2):574-81, February 1994 Abstract
  • Ganapathy V, Leibach F H, Expression and regulation of the taurine transporter in cultured cell lines of human origin., Advances In Experimental Medicine and Biology, 359, 51-7, 1994 Abstract
  • Jayanthi L D, Prasad P D, Ramamoorthy S, Mahesh V B, Leibach F H, Ganapathy V, Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter., Biochemistry, 32(45):12178-85, 16 Nov 1993 Abstract
  • Ramamoorthy S, Cool D R, Mahesh V B, Leibach F H, Melikian H E, Blakely R D, Ganapathy V, Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA lev, Journal of Biological Chemistry, 268(29):21626-31, 15 Oct 1993 Abstract
  • Ramamoorthy S, Leibach F H, Mahesh V B, Ganapathy V, Partial purification and characterization of the human placental serotonin transporter., Placenta, 14(4):449-61, July 1993 Abstract
  • Tiruppathi C, Miyamoto Y, Ganapathy V, Leibach F H, Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides., American Journal of Physiology, 265(1 Pt 1):G81-9, July 1993 Abstract
  • Pillion D J, Grizzle W E, Yang M, Meezan E, Stockard C R, Ganapathy V, Leibach F H, Myers R B, Haskell J F, Expression of IGF-II/Man-6-P receptors on rat, rabbit, and human colon epithelial cells., American Journal of Physiology, 264(6 Pt 2):R1101-10, June 1993 Abstract
  • Brandsch M, Miyamoto Y, Ganapathy V, Leibach F H, Regulation of taurine transport in human colon carcinoma cell lines (HT-29 and Caco-2) by protein kinase C., American Journal of Physiology, 264(5 Pt 1):G939-46, May 1993 Abstract
  • Ramamoorthy S, Prasad P D, Kulanthaivel P, Leibach F H, Blakely R D, Ganapathy V, Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast., Biochemistry, 32(5):1346-53, 9 Feb 1993 Abstract
  • Ramamoorthy S, Kulanthaivel P, Leibach F H, Mahesh V B, Ganapathy V, Solubilization and functional reconstitution of the human placental taurine transporter., Biochimica Et Biophysica Acta, 1145(2):250-6, 9 Feb 1993 Abstract
  • Leibach J W, Cool D R, Del Monte M A, Ganapathy V, Leibach F H, Miyamoto Y, Properties of taurine transport in a human retinal pigment epithelial cell line., Current Eye Research, 12(1):29-36, January 1993 Abstract
  • Prasad P D, Leibach F H, Mahesh V B, Ganapathy V, Specific interaction of 5-(N-methyl-N-isobutyl)amiloride with the organic cation-proton antiporter in human placental brush-border membrane vesicles. Transport and binding., Journal of Biological Chemistry, 267(33):23632-9, 25 Nov 1992 Abstract
  • Tiruppathi C, Brandsch M, Miyamoto Y, Ganapathy V, Leibach F H, Constitutive expression of the taurine transporter in a human colon carcinoma cell line., American Journal of Physiology, 263(5 Pt 1):G625-31, November 1992 Abstract
  • Simon B J, Kulanthaivel P, Burckhardt G, Ramamoorthy S, Leibach F H, Ganapathy V, Characterization of an ATP-driven H+ pump in human placental brush-border membrane vesicles., Biochemical Journal, 287 ( Pt 2), 423-30, 15 Oct 1992 Abstract
  • Ramamoorthy S, Cool D R, Leibach F H, Mahesh V B, Ganapathy V, Reconstitution of the human placental 5-hydroxytryptamine transporter in a catalytically active form after detergent solubilization., Biochemical Journal, 286 ( Pt 1), 89-95, 15 Aug 1992 Abstract
  • Ramamoorthy S, Leibach F H, Mahesh V B, Ganapathy V, Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line., Biochimica Et Biophysica Acta, 1136(2):181-8, 12 Aug 1992 Abstract
  • Ramamoorthy S, Leibach F H, Mahesh V B, Ganapathy V, Selective impairment of taurine transport by cyclosporin A in a human placental cell line., Pediatric Research, 32(1):125-7, July 1992 Abstract
  • Kulanthaivel P, Furesz T C, Moe A J, Smith C H, Mahesh V B, Leibach F H, Ganapathy V, Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (ba, Biochemical Journal, 284 ( Pt 1), 33-8, 15 May 1992 Abstract
  • Ramamoorthy S, Leibach F H, Mahesh V B, Ganapathy V, Active transport of dopamine in human placental brush-border membrane vesicles., American Journal of Physiology, 262(5 Pt 1):C1189-96, May 1992 Abstract
  • Sivakami S, Ganapathy V, Leibach F H, Miyamoto Y, The gamma-aminobutyric acid transporter and its interaction with taurine in the apical membrane of the bovine retinal pigment epithelium., Biochemical Journal, 283 ( Pt 2), 391-7, 15 Apr 1992 Abstract
  • Ramamoorthy S, Tiruppathi C, Nair C N, Mahesh V B, Leibach F H, Ganapathy V, Relative sensitivity to inhibition by cimetidine and clonidine differentiates between the two types of Na(+)-H+ exchangers in cultured cells., Biochemical Journal, 280 ( Pt 2), 317-22, 1 Dec 1991 Abstract
  • Tiruppathi C, Ganapathy V, Leibach F H, Transport of peptides in renal brush border membrane vesicles. Suitability of 125I-labelled tyrosyl peptides as substrates., Biochimica Et Biophysica Acta, 1069(1):14-20, 14 Oct 1991 Abstract
  • Ganapathy V, Miyamoto Y, Tiruppathi C, Leibach F H, Peptide transport across the animal cell plasma membrane: recent developments., Indian Journal of Biochemistry and Biophysics, 28(5-6):317-23, October 1991 Abstract
  • Cool D R, Leibach F H, Bhalla V K, Mahesh V B, Ganapathy V, Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR)., Journal of Biological Chemistry, 266(24):15750-7, 25 Aug 1991 Abstract
  • Ganapathy V, Leibach F H, Proton-coupled solute transport in the animal cell plasma membrane., Current Opinion In Cell Biology, 3(4):695-701, August 1991 Abstract
  • Miyamoto Y, Kulanthaivel P, Leibach F H, Ganapathy V, Taurine uptake in apical membrane vesicles from the bovine retinal pigment epithelium., Investigative Ophthalmology and Visual Science, 32(9):2542-51, August 1991 Abstract
  • Kulanthaivel P, Miyamoto Y, Mahesh V B, Leibach F H, Ganapathy V, Inactivation of taurine transporter by calcium in purified human placental brush border membrane vesicles., Placenta, 12(4):327-40, July 1991 Abstract
  • Ganapathy V, Leibach F H, Protons and regulation of biological functions., Kidney international. Supplement, 33, S4-10, July 1991 Abstract
  • Kulanthaivel P, Cool D R, Ramamoorthy S, Mahesh V B, Leibach F H, Ganapathy V, Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line., Biochemical Journal, 277 ( Pt 1), 53-8, 1 Jul 1991 Abstract
  • Miyamoto Y, Thompson Y G, Howard E F, Ganapathy V, Leibach F H, Functional expression of the intestinal peptide-proton co-transporter in Xenopus laevis oocytes., Journal of Biological Chemistry, 266(8):4742-5, 15 Mar 1991 Abstract
  • Miyamoto Y, Kulanthaivel P, Ganapathy V, Whitford G M, Leibach F H, Calcium-induced inhibition of taurine transport in brush-border membrane vesicles from rabbit small intestine., Biochimica Et Biophysica Acta, 1030(2):189-94, 14 Dec 1990 Abstract
  • Kulanthaivel P, Simon B J, Burckhardt G, Mahesh V B, Leibach F H, Ganapathy V, The ATP-binding site of the human placental H+ pump contains essential tyrosyl residues., Biochemistry, 29(48):10807-13, 4 Dec 1990 Abstract
  • Tiruppathi C, Ganapathy V, Leibach F H, Kinetic evidence for a common transporter for glycylsarcosine and phenylalanylprolylalanine in renal brush-border membrane vesicles., Journal of Biological Chemistry, 265(25):14870-4, 5 Sep 1990 Abstract
  • Miyamoto Y, Nakamura H, Hoshi T, Ganapathy V, Leibach F H, Uphill transport of beta-alanine in intestinal brush-border membrane vesicles., American Journal of Physiology, 259(3 Pt 1):G372-9, September 1990 Abstract
  • Cool D R, Leibach F H, Ganapathy V, High-affinity paroxetine binding to the human placental serotonin transporter., American Journal of Physiology, 259(2 Pt 1):C196-204, August 1990 Abstract
  • Kulanthaivel P, Simon B J, Leibach F H, Mahesh V B, Ganapathy V, An essential role for vicinal dithiol groups in the catalytic activity of the human placental Na(+)-H+ exchanger., Biochimica Et Biophysica Acta, 1024(2):385-9, 24 May 1990 Abstract
  • Tiruppathi C, Kulanthaivel P, Ganapathy V, Leibach F H, Evidence for tripeptide/H+ co-transport in rabbit renal brush-border membrane vesicles., Biochemical Journal, 268(1):27-33, 15 May 1990 Abstract
  • Cool D R, Leibach F H, Ganapathy V, Modulation of serotonin uptake kinetics by ions and ion gradients in human placental brush-border membrane vesicles., Biochemistry, 29(7):1818-22, 20 Feb 1990 Abstract
  • Tiruppathi C, Ganapathy V, Leibach F H, Evidence for tripeptide-proton symport in renal brush border membrane vesicles. Studies in a novel rat strain with a genetic absence of dipeptidyl peptidase IV., Journal of Biological Chemistry, 265(4):2048-53, 5 Feb 1990 Abstract
  • Tiruppathi C, Miyamoto Y, Ganapathy V, Roesel R A, Whitford G M, Leibach F H, Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains., Journal of Biological Chemistry, 265(3):1476-83, 25 Jan 1990 Abstract
  • Kulanthaivel P, Leibach F H, Mahesh V B, Cragoe E J Jr, Ganapathy V, The Na(+)-H+ exchanger of the placental brush-border membrane is pharmacologically distinct from that of the renal brush-border membrane., Journal of Biological Chemistry, 265(3):1249-52, 25 Jan 1990 Abstract
  • Miyamoto Y, Ganapathy V, Leibach F H, Peptidases and peptide transport in renal brush-border membrane vesicles from rats with acute renal failure., Journal of Pharmacology and Experimental Therapeutics, 252(1):98-103, January 1990 Abstract
  • Pillion D J, Haskell J F, Atchison J A, Ganapathy V, Leibach F H, Receptors for IGF-I, but not for IGF-II, on proximal colon epithelial cell apical membranes., American Journal of Physiology, 257(1 Pt 1):E27-34, July 1989 Abstract
  • Miyamoto Y, Tiruppathi C, Ganapathy V, Leibach F H, Multiple transport systems for organic cations in renal brush-border membrane vesicles., American Journal of Physiology, 256(4 Pt 2):F540-8, April 1989 Abstract
  • Miyamoto Y, Tiruppathi C, Ganapathy V, Leibach F H, Involvement of thiol groups in the function of the dipeptide/proton cotransport system in rabbit renal brush-border membrane vesicles., Biochimica Et Biophysica Acta, 978(1):25-31, 16 Jan 1989 Abstract
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Last Updated: Apr 5 2000.

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