COS Expertise Profile
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Dr. Michael Oliver Thorner

University of Virginia
School of Medicine
Internal Medicine
Chair     Appointed: 1997

University of Virginia
School of Medicine
Internal Medicine
Henry B. Mulholland Professor     Appointed: 1998

University of Virginia
School of Medicine
Internal Medicine
Endocrinology & Metabolism
Chief     Appointed: 1986
Michael Oliver Thorner
Mailing Address
Department of Internal Medicine, University of Virginia
Health Sciences Center Box 466
6th Floor Private Clinics Building
Room 6560
Charlottesville, Virginia 22908
United States
Contact Information
Phone: (804) 982-3297
Fax: (804) 979-4967
mot@virginia.edu
Qualifications
M.B., B.S., University of London (United Kingdom), Medicine/Surgery, 1970
M.R.C.P., Royal College of Physicians London, Internal Medicine, 1972
FLEX, 1979
FRCP, University of London, 1984
F.R.C.P., Royal College of Physicians London, Internal Medicine, 1984
D.Sc., University of London, 1988
D.Sc., University of London (United Kingdom), Neuroendocrinology, 1988
Expertise and Research Interests
Growth Hormone and Growth Hormone Releasing Hormone: Understanding the Mechanisms for the Decline of Growth Hormone with Age

It is established across species that growth hormone secretion declines with age. My research has concentrated on understanding the relationship between changes in body composition, age, gonadal steroids and growth hormone secretion. Low levels of growth hormone are associated with increased adiposity, particularly in visceral fat. This increased visceral fat is associated with increased cardiovascular risk and reduced life expectancy and morbidity. We are performing clinical studies to understand the mechanism by which the decline of growth hormone occurs in aging. Our primary hypothesis is that this is due to a progressive decline in GHRH secretion from the hypothalamus associated with neuronal cell loss in aging brain. A second series of studies are examining the possibility of restoring growth hormone secretion to that seen in young individuals either by administering GHRH or by administering growth hormone secretagogues. We also have a basic laboratory which is oriented towards understanding the signal transduction pathway for growth hormone action and a separate laboratory dealing with the molecular biology and physiology ofthe regulation of the receptor for the growth hormone releasing hormone. Our major effort is to establish whether enhanced growth hormone secretion in aging individuals is able to improve fitness and restore body composition to that found in younger individuals. It is hoped that this will improve well-being, reduce morbidity and improve life expectancy.
Other Expertise
Growth hormone releasing hormone as a therapeutic agent;
Growth hormone releasing peptide.

Consultant for the Pharmaceutical Industry.

Past Member: University of Virginia Research Policy Advisory Committee 1985-1987;
Medical Advisory Board, National Hormone and Pituitary Program 1984-1986; Food & Drug Administration Endocrinologic & Metabolic Drugs Advisory Committee 1984-1988;Biochemical Endocrinology Study Section, NIH MKSAP VIII Endocrinology and Metabolism Committee, American College of Physicians 1985-1988;
Council of Endocrine Society 1987-1990;
Board of Directors, Association of General Clinical Research Centers Program Directors, Inc. 1988-1991;
Center for Innovative Technology Institute of Biotechnology Advising Committee 1988-1990;
National Institutes of Health Reviewers Reserve (NRR)

Editorial Appointments:
Journal of Clinical Endocrinology and Metabolism 1981-1984;
Neuroendocrinology 1983-1987; 1994-present.

Albion O. Berstein Award, 1984;
Virginia's Outstanding Scientist, 1985;
Alpha of Virginia Chapter of the Alpha Omega Alpha--Membership;
Edwin B. Astwood Award, Endocrine Soc, 1992;
Excellence in Clinical Research, 1995;
Pituitary Society Award, 1995;
Theodore E. Woodward Award, 1996

Committees and Other Appointments

Member, Selection Committee for Residency Program, Department of Medicine, University of Virginia Medical School 1980-1982
Associate Director, Clinical Research Center, University of Virginia Medical Center, September 1981-February 1984
Councilor, Southern Section, A.F.C.R., 1981-1985
Member, Special Advisory Committee of the Center for Advanced Studies University of Virginia, September 1981-1992
Member, University of Virginia Faculty Forum for Scientific Research,September 1982-August 1989
Member, Programming Task Force of Program and Planning Committee for the University of Virginia Replacement Hospital
Director, University of Virginia General Clinical Research Center, March 1984-August 1997
Member, Medical Advisory Board, National Hormone and Pituitary Program, July 1, 1984-June 30, 1986
Member, Food and Drug Administration Endocrinologic and Metabolic Drugs Advisory Committee, July 1, 1984-June 30, 1988
Member, University of Virginia Research Policy Advisory Committee, February 1985-1987
Member, Biochemical Endocrinology Study Section, N.I.H., 1985-1989
Member, MKSAP VIII Endocrinology and Metabolism Committee, American College of Physicians, 1986-1988
Acting Director, Institute of Biodynamics, University of Virginia, May 1987-January 1989
Member, Council of Endocrine Society, 1987-1990
Member, Endocrine Society ENDO/ADA Liaison Committee, 1987- present
Member, Center for Innovative Technology Institute of Biotechnology Advising Committee, September 1, 1988-September 1, 1990
Member, Board of Directors, Association of General Clinical Research Centers Program Directors, Inc., 1988-1991
Member, Society of General Physiologists, 1988-1992
Member, National Institutes of Health Reviewers Reserve (NRR), July 1, 1989-June 30, 1993
Member, Alpha of Virginia Chapter of Alpha Omega Alpha, 1990
Member, Publication Committee, International Society of Neuroendocrinology,1991
Member, Endocrine Society Nominating Committee, 1991-present
President, General Clinical Research Center Program Directors' Association,1991-1993
Chair, Endocrine Society Nominating Committee, 1992-1993
Board of Directors, The American Pituitary Association, July 1, 1993-June 30, 1996
Member, American Pituitary Association Nominationsand Awards Committee, 1993-present
Board of Directors, Association for Patient-Oriented Research November 1998–present
President, Pituitary Society June 2000-present
President-Elect, Growth Hormone Research Society September 2000-present
Chair, Council on Diversity, University of Virginia School of Medicine August 2000-present

Editorial Appointments

Editorial Board, Journal of Clinical Endocrinology and Metabolism, 1981-1984
Editorial Board, Neuroendocrinology, 1983-1987
Editorial Board, Neuroendocrinology, 1994-present

Invited Lecturer

1975
National Institutes of Health, Bethesda, MD, 1975
Research Group, MSD, West Point, NY, 1975
Society for Drug Research, London, UK, 1975

1976
Joint Meeting of Experimental Medicine and Endocrine Sections, Royal Society of Medicine, London, UK, 1976
Third NICHD Workshop of the Testis, Pittsburgh, PA, 1976
Serono Symposium on Prolactin and Human Reproduction, Italy, 1976

1977
Symposium on Bromocriptine, Stockholm, Sweden, 1977
Advanced Medicine Symposium, Royal College of Physicians, London, UK, 1977

1978
HEW Bureau of Drugs Seminar, Rockville, MD, 1978
Endocrine Grand Rounds, National Institutes of Health, Bethesda, MD, 1978
International Symposium on Dopaminergic Ergot Derivatives and Motor Function, Stockholm, Sweden 1978
International Symposium on Recent Advances in Neuroendocrinology, Sao Paulo, Brazil, October 1978

1979
International Symposium on Ergot Alkaloids, New York University, NY, May 1979 State ofthe Art Lecture, 61st Annual Meeting of the Endocrine Society, Anaheim, CA, June 1979
12th Miles International Symposium on Polypeptide Hormones, Johns Hopkins Medical School, Baltimore, MD, July 1979
Symposium on Central and Peripheral Regulation of Prolactin Function, Taormina, Italy, October 1979
3rd Annual Symposium on Recent Advances in Clinical Therapeutics, Ohio State University, December 1979

1980
Visiting Professor, University of Manitoba, Winnipeg, Canada, January 1980
VI InternationalCongress of Endocrinology, Melbourne, Australia, February 1980
Prolactin 1980 and Beyond, Adelaide, Australia, February 1980
NINCDS Workshop: Neurosecretion and Brain Peptides: Implications for Brain Function and Neurological Disease, The Cloister, Sea Island, GA, March 12-14, 1980
International Sardinian Symposium, Clinical Pharmacology of Apomorphine and Other Dopaminomimetics, Sardinia, Italy, September 28-October 2,1980
14th Brazilian Congress of Endocrinology, Fortaleza, Brazil, October 5-10, 1980

1981
Research Seminar: Reproductive Endocrinology Series, University of California, San Francisco, CA, February 1981
The Endocrine Society 1981 Update in Endocrinology Seminar for Science Writers, The Rockefeller University, NY, March 1981
III Course on Transsphenoidal Surgery, University of Guadalajara, Mexico, March 1981
National Institute of Mental Health, Psychoneuroendocrinology Symposium, McMaster University, Ontario, Canada, June 1981
XVI Canadian Congress of Neurological Sciences, Calgary, Canada, June 1981
Aging Brain and Ergot Alkaloids, Rome, Italy, October 1981
International Workshop on Lisuride and Other Dopamine Agonists, Berlin, Germany, December 2-5, 1981
Visiting Professor, University of Massachusetts, Worcester, MA, December 21-22, 1981

1982
NIH Workshop, The Role of Proteins and Peptides in Control of Reproduction, Bethesda, MD, February 16-17, 1982
Visiting Professor, Dalhousie University, Halifax, Nova Scotia, April 1982
Visiting Professor, Massachusetts GeneralHospital, Boston, MA, May 18, 1982
The 5th National Congress of Obstetrics and Gynaecologists (KOGI V),
Bandung, Indonesia, June 7-11, 1982
13th Biennial Congress of the Association of Physicians, Pretoria, South Africa, July 4-7, 1982
International Course on Sterility in Woman, Buenos Aires, Argentina, October 1-2, 1982
Thirty Fourth Annual Postgraduate Assembly of the Endocrine Society, Dearborn, MI, October 4-8, 1982

1983
Gordon Research Conference on Prolactin, Ventura, CA, February 14-18, 1983
Third Annual Brain-Pituitary Symposium, Memphis, TN, March 3-4, 1983
The Endocrine and Metabolism Dinner, FASEB Meetings, The American Physiological Society, Chicago, IL, April 11-14, 1983
International Symposium on Pituitary Tumors, Boston, MA,June 4-7, 1983
XI World Congress on Fertility and Sterility, Dublin, Ireland, June 26-July 1, 1983
Visiting Professor, Mayo Clinic, Rochester, MN, July 17-20, 1983
Population Research Center Director's Meeting, Seattle, WA, July 21-23, 1983
Recent Advances in Internal Medicine Course, American College of Physicians, Vanderbilt University, Nashville, TN, September 21, 1983
Workshop: Clinical Aspects of the Hypothalamus, Munich, Germany, October 14-15, 1983
Philip Sarver Visiting Professor in Endocrinology and Metabolism, USC School of Medicine, Los Angeles, CA, October 25-28, 1983
Visiting Professor, The Mount Sinai Medical Center, NY, November 16-17, 1983
Human Growth Hormone Symposium, Baltimore, MD, November 20-22, 1983

1984
4th Pituitary Workshop (Japan), Osaka, Japan, February 9, 1984
First Symposium of the European Neuroendocrine Association, Basle, Switzerland, March 4-7, 1984
3rd Joint Meeting of British Endocrine Societies, University of Edinburgh, Scotland, March 27-31, 1984
International Meeting for Radioimmunology, Lyon, France, April 12-14, 1984
Basic Concepts in Endocrinology Course, The Endocrine Society, George Washington University, Washington, DC, May 2-4, 1984
Michigan State University-Upjohn Pharmaceutical SeminarSeries, East Lansing, MI, May 23-25, 1984
VII International Congress of Endocrinology, Quebec City, Quebec, Canada, July 1-7, 1984, Symposium Speaker
Endocrinology Postgraduate Course, Milton S. Hershey Medical Center, Geisinger Medical Center and American College of Physicians,Atlantic City, NJ, September 27-29, 1984
The American Academy of Neurological Surgery, Hot Springs, VA, October 17-20, 1984
MSTP Program and Department of Pharmacology, University of Iowa, Iowa City, IA, December 12,1984

1985
66th Annual Session, American College of Physicians, Washington, DC,March 28-31, 1985
Post-graduate Course, The University of Michigan, Ann Arbor, MI, May 16,1985
Population Research Center Director's Meeting, University of Michigan, Ann Arbor, MI, May 23-24, 1985
International Symposium 'Recent Advances in Growth Hormone Regulation and Action: GRF and Somatomedins', Paris, France, May 31-June 1, 1985
XV Acta Endocrinologica Congress, Helsinki, Finland, August 5-9, 1985
The Laurentian Hormone Congress, Banff, Canada, September 8-15, 1985
2nd Symposium of the European Neuroendocrine Association, Milan, Italy, October 15-17, 1985
Industrial Relevance
1986
67th Annual Session, American College of Physicians, San Francisco, CA, April 10-13, 1986
2nd International Growth and Development Association Meeting on 'Future Clinical Use of Human Growth Hormone,' Sicily, Italy, May 19-22, 1986
68th Annual Meeting, The Endocrine Society, Anaheim, CA, June 25-27, 1986
Serono Acromegaly Centennial Symposium, San Francisco, CA, June 29-July 1, 1986
First International Congress of Neuroendocrinology, San Francisco, CA, July 9-11, 1986
The XXX International Congress of Physiological Sciences, Vancouver, British Columbia, July 13-18, 1986
14th International Cancer Congress, Budapest, Hungary, August 24-27, 1986
The Endocrine Society of Australia 29th Annual Meeting, Brisbane, Australia, August 31-September 3,1986, Harrison Memorial Lecturer
NICHD International Workshop on Advances in Research on Human Growth,
Airlie, VA, September 14-16, 1986
Annual Meeting of the Swiss Endocrine Society, Bern, Switzerland, October 25, 1986,
Plenary Lecturer II World Congress on Fertility and Sterility, Singapore, October 26-31, 1986
Foundation for Growth Science Symposium, Tokyo, Japan, November 1-2, 1986

1987
Society for the Study of Human Biology Symposium on the Physiology of Growth, Oxford, England, April 13-14, 1987
Modern Diagnosis and Treatment of Secretory and Non Secretory Pituitary Neoplasia, Long Island Jewish Medical Center, May 8, 1987
Workshop on Biosynthetic GH and GHRH: Basic and Clinical Aspects, Instituto Scientifico H, San Raffaele, Milan, Italy, June 26, 1987
Growth Hormone Basic and Clinical Aspects, Nordisk Insulin Symposium No. 1, Stockholm, Sweden, June 29-July 1, 1987
The Pituitary at Aspen, July 9-11, 1987
Inserm Conference on The Anterior Pituitary Gland Fundamental and Pathological Aspects, Seillac, France, September 20-24, 1987
Sandostatin Consensus Round Table, Amsterdam, Netherlands, October 25-27,1987
Abbott Laboratories Distinguished Speaker Series, Abbott Park, IL, December 8, 1987

1988
David Rabin Lecturer, Vanderbilt School of Medicine, Nashville, TN, March 3, 1988
Company of Biologists, Ltd. Discussion Meeting 'The Secretory Event,' Greek Orthodox Academy, Kolimpari, Crete, Greece, March 19-26, 1988
Clinical Endocrinology Postgraduate Course, Massachusetts General Hospital, Boston, MA, April 11, 1988
Beth Israel Seminar Series, Beth Israel Hospital, Harvard University, Boston, MA, April 12, 1988
The Endocrine Society Annual Meeting, New Orleans, LA, June 11, 1988,
Clinical Day Lecture: 'Concepts and Management of Prolactinoma'
International Symposium on Growth Abnormalities, Bologna, Italy, June 22-24, 1988, Invited Lecturer: 'Therapy with Growth Hormone Releasing Factor'
8th International Congress of Endocrinology, Kyoto, Japan, July 17-23, 1988, Meet the Professor Session: 'Hyperprolactinemia'
International Symposium on Hormone Regulation of Growth, Vienna,
October 7-8, 1988, Invited Lecturer, 'Regulation of Growth Hormone
Secretion in Man'

1988
Postgraduate Assembly of the Endocrine Society, Philadelphia, PA,
October 30-31, 1988, Lecture: 'Prolactin Secreting Adenomas: Pathogenesis and Implications for Treatment,' Workshop: 'Evaluation
of Pituitary Function in Patients with Pituitary Adenomas'
Waldo B. Edwards Seminar, St. Joseph Hospital, Kirkwood, MO, November 2, 1988,
Invited Lecturer: 'Growth Hormone Secretion in Health and Disease'

1989
National Eye Institute Workshop Meeting on Somatostatin Analogs in Diabetic Retinopathy, National Institutes of Health, March 16-17, 1989, Participant
British Endocrine Society Meeting, Manchester, April 10-13, 1989, Clinical Endocrinology Trust Lecturer
Pituitary Society of Houston, State Medical Association of Texas Symposium on Pituitary Disorders, Fort Worth, TX, May 13, 1989, Invited Lecturer: 'Medical Therapy for Nonprolactin Tumors'
International Symposium on Somatostatin, Montreal, Canada, August 6-9, 1989, Invited Lecturer: 'Physiological Role of Somatostatin on Growth Hormone Regulation in Man'
Bellagio Study and Conference Center, October, 1989, The Rockefeller Foundation, Scholar in Residence
Workshop on Current Trends of Growth Related Research, Haifa, Israel, October 24-27, 1989, Invited Lecturer: 'Treatment of Growth Hormone Deficiency with Growth Hormone Releasing Hormone'

1990
The Science Museum of Virginia, Richmond, VA, January 18, 1990, Invited Lecturer: 'An Experiment with Nature: An Opportunity for Clinical Investigation'
Philadelphia Endocrine Society Symposium on Prolactinoma, February 7, 1990, Invited Lecturer
American Association for the Advancement of Science Annual Meeting Symposium, New Orleans, LA, February 19, 1990, Invited Lecturer:
'Patient Oriented Research: An Unremitting Record of Successes,” 'Ectopic Growth Hormone Releasing Hormone Secretion (GHRH) - A Clinical Opportunity for a Breakthrough in Biology'
German Endocrine Society, Hannover, Germany, March 14-17, 1990,Plenary Lecturer: 'Regulation of Growth Hormone Secretion and Its Therapeutic Implication'
Lilly Clinical Scholar and Visiting Professor, Lilly Research Laboratories and the University of Indiana, March 26-28, 1990
Seminar Speaker and Consultant for Program Project, Center for Reproductive Science, Northwestern University, Evanston, IL, April 22-23, 1990
American College of Physicians, Update in Endocrinology and Metabolism, Toronto, Canada, May 9-11, 1990, Invited Lecturer: 'Acromegaly:Contemporary Management'
2nd International Congress of Neuroendocrinology, Bordeaux,France, June 20-23, 1990, Invited Lecturer: 'Regulation of Human Growth Hormone Secretion'
Reproductive Issues and the Aging Male, Center for Population Research National Institute of Child Health and Human Development, National Institutes of Health, November 26-27, 1990, Invited Lecturer, 'Regulation of Growth Hormone Secretion With Age'

1991
Division of Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Visiting Professor, February 11-12, 1991
Workshop on Future Approaches to the Basic Neurobiology of Sleep, (NationalCommission on Sleep Disorders Research), Woods Hole, MA, March 5, 1991
Visiting Professor, Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, MD, March 26, 1991
Endocrine Post Graduate Course, Harvard Medical School, April 8, 1991,
Invited Lecturer
Serono Symposium, Growth Disorders: The State of the Art, Bari, Italy, April 9-12, 1991,Invited Lecturer
Serono Symposium, Frontiers in Reproductive Endocrinology, Washington, DC, April 24-25, 1991, Invited Lecturer, “Neuroendocrinology of Prolactin Secretion and Growth Hormone Hypersecretion'
Leon Smelo Memorial Lecture, Baptist Medical Center-Montclair Hospital, Birmingham, AL, May 29, 1991,Invited Lecturer, 'Clinical and Therapeutic Aspects in Acromegaly'
Reproductive Endocrine Basic Science Seminar Series, Massachusetts General Hospital, May 31, 1991, Invited Lecturer, 'Some Basic and Clinical Aspects on Regulation of Growth Hormone Secretion'
Sandoz Symposium on Physician's Dilemma: Management of Patients With Pituitary Tumors and Acromegaly, at the 73rd Annual Meeting of the Endocrine Society, Washington, DC, June 22, 1991, 'Pathophysiology of Acromegaly and Pituitary Tumors'
VIth International Congress of Auxology, Madrid, Spain, September 13-15, 1991, Invited Lecturer, 'GHRH and GHRP Are Secretagogues of Growth Hormone'

1992
Industrial Symposium on Importance of Biological Rhythms for Industry: Biological Rhythms and the Agricultural Industry, Commonwealth of Virginia Center for Innovated Technology at Dulles Airport, Chantilly, VA, February 9, 1992, 'Implications for Animal and Human Growth'
Pennsylvania State University Seminar Speaker, February 14, 1992, 'The Role of GHRH and Somatostatin in the Regulation of Growth Hormone Secretion in Man'
Visiting Professor, University of Colorado Endocrine Division, March 10-11, 1992, Research Conference - 'Regulation of GH Secretion,' Colorado Endocrine Society - 'Diagnostic and Therapeutic Approaches to Pituitary Tumors', Grand Rounds - 'Acromegaly Dilemmas of Diagnosis and Treatment'
Visiting Professor, Beth Israel Hospital, Boston, MA, May 14-15, 1992, Medical Grand Rounds - 'Acromegaly: Pathophysiology, Diagnosis and Therapy,' Endocrine Grand Rounds - 'Physiology and Pathophysiology of Growth Hormone Secretion'
Edwin B. Astwood Lecture at the 74th Annual Meeting of the Endocrine Society, San Antonio, TX, June 27, 1992, 'Growth Hormone: Regulation, Secretion and Metabolic Actions in Man'
Visiting Professor, Universita Di Brescia, Cattedra di Clinica Medica, Brescia, Italy, September 7-12, 1992, 'Regulation of Growth Hormone Secretion in Man and its Metabolic Actions'
Pediatric AIDS Foundation Seventh Think Tank 'HIV and Physical and Cellular Growth', Santa Barbara, CA, September 18-20, 1992, 'Potential
Endocrine and Non-Endocrine Causes of Growth Failure in Children with AIDS'
Novo Nordisk at Workshop on Growth No. 5, Moltkes Palace in Copenhagen,Denmark, September 24-26, 1992, Invited Lecturer, 'GH Releasing Peptides - Mode of Action and Therapeutic Possibilities'
14th International Symposium on Growth and Growth Disorders, Budapest, Hungary, October 23-24, 1992, Plenary Lecturer, 'On the Discovery of GHRH'
7th Annual Advances and Controversies in Internal Medicine Course, The Greenbrier, White Sulphur Springs, WV, October 29-November 1, 1992, Invited Lecturer, 'Prolactin Secreting Pituitary Tumors,''Acromegaly,' and 'Cushing's Disease'
Pituitary Tumor Workshop at Congress of Neurological Surgeons 42nd Annual Meeting, Sheraton Washington Hotel, October 31-November 5, 1992, Invited Lecturer, 'Endocrine Evaluation of Patients with Cushing's Disease and Non-Functioning Pituitary Adenomas'

1993
Colorado Diabetes/Endocrine Institute Conference, Aspen/Snowmass, CO,
January 26-30, 1993, Invited Lecturer, 'Prolactin Secreting Pituitary
Tumors'
Visiting Professor, City-Wide Endocrine Conference Series at University of Minnesota, Minneapolis, MN, February 4, 1993, 'Human growth hormone secretion'
Baltic Endocrine Conference Kiel, Growth HormoneTherapy in Adults: New Aspects 1993, February 27, 1993, Invited Lecturer, 'Regulation of Growth Hormone Secretion in Man'
Visiting Professor, University of Brussels Endocrinology Seminar, March 1, 1993, 'Regulation on Growth Hormone Secretion'
Nutrition, Endocrinology and Disease Satellite Conference to the Regional American College of Physicians' Annual Meeting at the Pennington Biomedical Research Center, Baton Rouge, LA, March 4, 1993, Invited Lecturer, 'Regulation of GH Secretion and its Potential Importance for Changes in Body Composition with Aging'
VI International Prolactin Congress, Paris, France, August 30 - September 3, 1993, Invited Lecturer, 'Hyperprolactinemia and Prolactinomas'
Frontiers of Paediatric Neuroendocrinology, Royal College of Physicians, London, England, September 6-8, 1993, Invited Lecturer, 'Current Status of Therapy with GH-Releasing Neuropeptides'
Serono Symposia, USA Symposium on the Somatotrophic Axis and the Reproductive Process in Health and Disease, Baltimore, MD, October 28-31, 1993, Co-Chair and Lecturer, 'Growth Hormone: A Current Perspective'
Endocrine Society's Annual Postgraduate Assembly, San Francisco, CA,
November 12-18, 1993, Invited Lecturer, 'A Current Management of Hyperprolactinemia'

1994
TheFifth Annual Williamsburg Geriatrics Conference, Williamsburg, VA,
March 23-27, 1994, Invited Lecturer, 'What Every Clinician Needs to Know About Rehabilitation: An Insider's View'
The Society of Neurological Surgeons 85th Meeting, Charlottesville, VA,April 24-27, 1994, Invited Lecturer, 'Prolactinoma: The Molecular
Biology of Dopamine Agonist Resistance and Indications for Surgical Management'
Visiting Professor, Walter Reed Army Medical Center, Washington, DC,
October 13, 1994, 'GH Regulation by GHRH and GHRP' and October 14, 1994, 'Pituitary Tumors: Evaluation and Management'
18th International Symposium on Growth Hormone and Growth Factors in
Endocrinology and Metabolism, Gothenburg, Sweden, October 21-22, 1994, Chair and Plenary Lecturer, 'Recent Advances in our Understanding of Growth Hormone Deficiency in Adults'

1995
The Twentieth Annual American Society of Andrology Annual Meeting, Raleigh, NC, April 2, 1995, Endocrine Assessments in Andrology Symposium, “Evaluation and Managementof Pituitary Tumors in Men”
European Society for Paediatric Endocrinology Annual Meeting, Edinburgh,UK, June 25-28, 1995, Plenary Lecturer, “Novel Neuropeptides”
Visiting Professor, Burroughs-Wellcome Fund Visiting Professorship, Royal Victoria Infirmary, Newcastle Upon Tyne, June 29, 1995, Children’s Hospital, Manchester, June 30, 1995, University College
Hospital/Middlesex Hospital, July 5, 1995, “The Potential of Growth
Hormone Secretagogues in Growth Hormone Deficiency States,” and the
Royal Society of Medicine, July 5, 1995, “Growth Hormone Releasing
Hormone and its Receptor; Basic and Clinical Aspects”
M.D. Anderson Cancer Center, University of Texas Pituitary Tumor Conference,Houston, TX, November 4, 1995, “Prolactinomas”

1996
American Geriatrics Society 53rd Annual Scientific Meeting, Chicago, IL, May 2-5, 1996, “The Decline of Growth Hormone with Age: A Therapeutic Challenge”
Recent Progress in Hormone Research 52nd Conference, Stevenson, WA,
August 17-21, 1996, “GHRH and growth hormone releasing peptide as
therapeutic agents to enhance growth hormone secretion in disease and
aging”
American Clinical and Climatological Association Annual Meeting, Colorado Springs, CO, October 20-23, 1996, “The Age Dependent Decline of Growth Hormone Secretion: Significance and Potential Reversibility”
2nd International Symposium on Growth Hormone Secretagogues, Tampa, FL, February 13-16, 1996, Invited Lecturer, “Interactions of Exogenous GH Secretagogues”

1997
Medical Grand Rounds Conference, Cedars-Sinai Medical Center, Los Angeles, CA, March 28, 1997, “Medical Treatment of Pituitary Tumors”
1997 Postgraduate Seminar, The Endocrine Society of Australia, Adelaide, South Australia, April 11-13, 1997, Invited Lecturer, “Recent Advances in the Treatment of Pituitary Tumours: New Drugs,” “Growth Hormone in Ageing”, Panel Member, Clinical Symposium,“ Cushing’s Disease,” Panel Member, Clinical Symposium, “Disorders of Growth”
Growth Hormone Research Society Workshop, “The Diagnosis andTreatment
of Adult Growth Hormone Deficiency (GHD),” Port Stephens, New South
Wales, Australia, April 15-17, 1997, Participant
David Orth Symposium, Normal and Abnormal Hypothalamic, Pituitary and
Adrenal Function, Vanderbilt University Medical Center, Nashville, TN,
June 15-16, 1997, Invited Lecturer, “Is It Possible and Is It Beneficial to Reverse the Somatopause?”
National Center for Research Resources Strategic Planning Forum, “Choices and Challenges: Future Directions for NCRR,” Herndon, VA,September 10-11, 1997, Participant
Medicine Grand Rounds, University of Washington School of Medicine, Seattle, WA, October 23, 1997, “The Decline of Growth Hormone With Aging”
Endocrine Days, Seattle, WA, October 24, 1997, Invited Lecturer, “Growth Hormone Therapy in Adults,” “Medical and Surgical Treatment of
Pituitary Tumors”
Third Annual Pituitary Days Conference, Charlottesville, VA, November 14-15, 1997, Invited Lecturer, “Medical Approach to a Pituitary Tumor,” Focus Group, “Prolactinoma,” Patient Forum Panel Member, Physician Case Conference Participant, Lecture,“Update on Molecular Biology of Pituitary Tumors”
Keywords
COS Keywords: Body Composition; Endocrinology; Growth Hormone; Metabolism; Neuroendocrinology; Pharmacology
Additional Terms: Body Composition; Clinical Investigation; Clinical Pharmacology and Therapeutics; Endocrinology; Growth Hormone; Growth Hormone Releasing Hormone; Metabolism; Neuroendocrinology
Languages
Reading, Writing, Speaking:
French: (Functional, Functional, Functional)
German: (Functional, Functional, Functional)
Memberships
Alpha Omega Alpha
American Association for the Advancement of Science
American Clinical and Climatological Association
American College of Physicians
American Diabetes Association
American Federation for Medical Research
American Physiological Society
American Society for Clinical Investigation
Association of American Physicians
Endocrine Society
International Society of Neuroendocrinology
Society for Neuroscience
Society of Endocrinology (UK)
Southern Society for Clinical Investigation
Honors and Awards
2000, Fellow, American Academy of Arts and Sciences
2000, Endocrine Society Distinguished Physician Award
1999, American Society of Internal Medicine John Phillips Memorial Award, American College of Physicians
1996, Theodore E. Woodward Award, American Clinical and Climatological Association
1995, General Clinical Research Center Program Seventh Annual Award for Excellence in Clinical Research
1995, Pituitary Society Annual Award for Contributions to Understanding Pituitary Disease
1992, Edwin B. Astwood Award, Endocrine Society
1992, Edwin B. Astwood Award, Endocrine Society
1991, Virginia Chapter of the Alpha Omega Alpha
1985, Virginia's Outstanding Scientist
1984, Albion O. Bernstein Award
Previous Positions
1990-1998, Kenneth R. Crispell Professor, Medicine, University of Virginia, School of Medicine, Internal Medicine, Endocrinology and Metabolism
1984-1997, Director, University of Virginia, School of Medicine, Internal Medicine, General Clinical Research Center
1982-1990, University of Virginia, Professor
1977-1982, University of Virginia, Associate Professor of Medicine
1974-1977, St. Bartholomew's Hospital University of London, Honorary Lecturer and Lecturer
1974, St. Bartholomew's Hospital University of London, Lecturer in Chemical Pathology
1970-1974, University of London, Housestaff Training
Patents
Characterization of the Growth Hormone Releasing Hormone Receptor, United States, Patent No. 5973114, 1999, (Thorner et al). Abstract

Molecular Cloning of the Ovine Pituitary Growth Hormone Releasing Hormone Recepto, United States, Patent No. 5852187, 1998, (Thorner et al). Abstract

Nucleic Acid Encoding the Growth Hormone Releasing Hormone Receptor, United States, Patent No. 5591641, 1997, (Thorner et al). Abstract

Cloning of a Gene Encoding for the Growth Hormone Releasing Hormone, United States, Patent No. 5644046, 1997, (Thorner et al). Abstract

Nucleic Acid Molecule Encoding the Porcine Growth Hormone Releasing Hormone Receptor, United States, Patent No. 5583010, 1996, (Thorner et al). Abstract

Isolation and Characterization of the Growth Hormone Releasing Hormone Receptor, Australia, Patent No. 672188, 1996, (Thorner et al).

Isolation, Characterization, and Protein Sequencing of the Growth Hormone Releasing Hormone Receptor, Australia, Patent No. 673188, 1996, (Thorner et al).

Isolation and Characterization of the Pituitary Receptor for Growth Hormone Releasing Factor, United States of America, Patent No. 902826, 1992, Thorner, et. al.. Abstract

Cloning of the Pituitary Receptor for Growth Hormone Releasing Hormone, United States of America, Patent No. 947672, 1992, . Abstract

Method for Increasing Growth Hormone Secretion, United States of America, Patent No. 5036045, 1991, (Thorner). Abstract

Apparatus and Method for Pulsed Administration Growth Promoting Agents, United States of America, Patent No. 4747825, 1988, (Linkie/Thorner). Abstract

Cloning of Human Growth Hormone Releasing Factor Gene, United States of America, Patent No. Pending Application No. 512923, 1983, (Thorner). Abstract
Funding Received
  • National Institutes of Health (NIH):Growth Hormone & Physical Training in Older Persons, $175,378, from Jul 1, 1992 to Jun 30, 1998.

  • National Institutes of Health (NIH):Reversal of Decline of GH Secretion of Aging, $226,620, from Dec 1, 1997 to Nov 30, 2002.

  • National Institutes of Health (NIH):Growth Hormone Releasing Factor Receptor, $126,692, from Dec 1, 1997 to Nov 30, 1998.

  • Cancer Center Support Grant, National Institutes of Health (NIH), $2,512,356, 8/95 - 7/99

Publications
  • Nass R, Gilrain J, Anderson S, Gaylinn B, Dalkin A, Day R, Peruggia M, Thorner MO, High plasma growth hormone (GH) levels inhibit expression of GH secretagogue receptor messenger ribonucleic acid levels in the rat pituitary, Endocrinology, 141(6):2084-9, June 2000 Abstract

  • Gaylinn BD, Dealmeida VI, Lyons CE Jr, Wu KC, Mayo KE, Thorner MO, The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH, Endocrinology, 140(11):5066-74, November 1999 Abstract

  • Thorner MO, Strasburger CJ, Wu Z, Straume M, Bidlingmaier M, Pezzoli SS, Zib K, Scarlett JC, Bennett WF, Growth hormone (GH) receptor blockade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH, Journal of Clinical Endocrinology and Metabolism, 84(6):2098-103, June 1999 Abstract

  • Skinner MM, Nass R, Lopes B, Laws ER, Thorner MO, Growth hormone secretagogue receptor expression in human pituitary tumors, Journal of Clinical Endocrinology and Metabolism, 83(12):4314-20, December 1998 Abstract

  • Silva CM, Isgaard J, Thorner MO, Cytokines in endocrine function, Advances in Protein Chemistry, 52, 199-221, 1998 Abstract

  • Chapman IM, Pescovitz OH, Murphy G, Treep T, Cerchio KA, Krupa D, Gertz B, Polvino WJ, Skiles EH, Pezzoli SS, Thorner MO, Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults, Journal of Clinical Endocrinology and Metabolism, 82(10):3455-63, October 1997 Abstract

  • Clasey JL, Bouchard C, Wideman L, Kanaley J, Teates CD, Thorner MO, Hartman ML, Weltman A, The influence of anatomical boundaries, age, and sex on the assessment of abdominal visceral fat, Obesity Research, 5(5):395-401, September 1997 Abstract

  • Lopes MB, Gaylinn BD, Thorner MO, Stoler MH, Growth hormone-releasing hormone receptor mRNA in acromegalic pituitary tumors, American Journal of Pathology, 150(6):1885-91, June 1997 Abstract

  • Chapman IM, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KY, Skiles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO, Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects, Journal of Clinical Endocrinology and Metabolism, 81(12):4249-57, December 1996 Abstract

  • Bergendahl M, Vance ML, Iranmanesh A, Thorner MO, Veldhuis JD, Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men, Journal of Clinical Endocrinology and Metabolism, 81(2):692-9, February 1996 Abstract

  • Aloi JA, Gertz BJ, Hartman ML, Huhn WC, Pezzoli SS, Wittreich JM, Krupa DA, Thorner MO, Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects [see comments], Journal of Clinical Endocrinology and Metabolism, 79(4):943-9, October 1994 Abstract

  • Chapman IM, Hartman ML, Straume M, Johnson ML, Veldhuis, Enhanced sensitivity GH chemiluminescence assay reveals lower post-glucose nadir GH concentrations in men than women, Journal of Clinical Endocrinology and Metabolism, 78, 1312-1319, 1994

  • Gaylinn BD, Lyons CE, Zysk JR, Clarke IJ, Thorner MO, Photo-affinity cross-linking to the pituitary receptor for growth hormone releasing hormone, Endocrinology, 135, 950-956, 1994

  • Aloi JA, Gertz BJ, Hartman ML, Huhn WC, Pezzoli SS, Wittreich JM, Krupa DA, Thorner MO, Neuroendocrine responses to a novel growth hormone secretagogue, L-692, 429, in healthy older subjects, Journal of Clinical Endocrinology and Metabolism, 79, 943-949, 1994

  • Hartman ML, Clayton PE, Johnson ML, Celniker A, Perlman AJ, Alberti KG, Thorner MO, A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans, Journal of Clinical Investigation, 91(6):2453-62, June 1993 Abstract

  • Veldhuis JD, Iranmanesh A, Evans WS, Lizarralde G, Thorner MO, Vance ML, Amplitude suppression of the pulsatile mode of immunoradiometric luteinizing hormone release in fasting-induced hypoandrogenemia in normal men, Journal of Clinical Endocrinology and Metabolism, 76(3):587-93, March 1993 Abstract

  • Gaylinn BD, Harrison JK, Zysk Jr, Lyons CE, Lynch Kr, Thorner MO, Molecular cloning and expression of human anterior pituitary receptor for growth hormone-releasing hormone, Molecular Endocrinology, 7, 77-84, 1993

  • Holl RW, Hartman ML, Veldhuis JD, Taylor WM, Thorner MO, Thirty-second sampling of plasma growth hormone in man: correlation with sleep stages, Journal of Clinical Endocrinology and Metabolism, 72(4):854-61, April 1991 Abstract

  • Holl RW, Thorner MO, Leong DA, Cytosolic free calcium in normal somatotropes: effects of forskolin and phorbol ester, American Journal of Physiology, 256(3 Pt 1):E375-9, March 1989 Abstract

  • Faria AC, Veldhuis JD, Thorner MO, Vance ML, Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin, Journal of Clinical Endocrinology and Metabolism, 68(3):535-41, March 1989 Abstract

  • Moller DE, Moses AC, Jones K, Thorner MO, Vance ML, Octreotide suppresses both growth hormone (GH) and GH-releasing hormone (GHRH) in acromegaly due to ectopic GHRH secretion, Journal of Clinical Endocrinology and Metabolism, 68(2):499-504, February 1989 Abstract

  • Sortino MA, Evans WS, Speciale C, Thorner MO, Scapagnini U, MacLeod RM, Canonico PL, Gonadotropin-releasing hormone-stimulated phosphoinositide hydrolysis in the anterior pituitary. Modulation by protein kinase C but not by cyclic nucleotides, Neuroendocrinology, 48(5):544-50, November 1988 Abstract

  • Ho KY, Thorner MO, Krieg RJ Jr, Lau SK, Sinha YN, Johnson ML, Leong DA, Evans WS, Effects of gonadal steroids on somatotroph function in the rat: analysis by the reverse hemolytic plaque assay, Endocrinology, 123(3):1405-11, September 1988 Abstract

  • Thorner MO, Vance ML, Growth hormone, 1988, Journal of Clinical Investigation, 82(3):745-7, September 1988 Abstract

  • Thorner MO, Holl RW, Leong DA, The somatotrope: an endocrine cell with functional calcium transients, Journal of Experimental Biology, 139, 169-79, September 1988 Abstract

  • Martha PM Jr, Blizzard RM, McDonald JA, Thorner MO, Rogol AD, A persistent pattern of varying pituitary responsivity to exogenous growth hormone (GH)-releasing hormone in GH-deficient children: evidence supporting periodic somatostatin secretion, Journal of Clinical Endocrinology and Metabolism, 67(3):449-54, September 1988 Abstract

  • Thorner MO, Rogol AD, Blizzard RM, Klingensmith GJ, Najjar J, Misra R, Burr I, Chao G, Martha P, Mcdonald J, et al, Acceleration of growth rate in growth hormone-deficient children treated with human growth hormone-releasing hormone, Pediatric Research, 24(2):145-51, August 1988 Abstract

  • Ho KY, Thorner MO, Therapeutic applications of bromocriptine in endocrine and neurological diseases, Drugs, 36(1):67-82, July 1988 Abstract

  • Veldhuis JD, Faria A, Vance ML, Evans WS, Thorner MO, Johnson ML, Contemporary tools for the analysis of episodic growth hormone secretion and clearance in vivo, Acta Paediatrica Scandinavica. Supplement, 347, 63-82, 1988 Abstract

  • Krishnan KR, Manepalli AN, Ritchie JC, Rayasam K, Melville ML, Thorner MO, Rivier JE, Vale WW, Nemeroff CB, Growth hormone response to growth hormone-releasing factor in depression, Peptides, 9 Suppl 1, 113-6, 1988 Abstract

  • Davis M, Nassberg B, Borges JL, Iranmanesh A, Lizzaralde G, Santen RJ, Drake C, Rogol AD, Kaiser DL, Thorner MO, et al, Actions of calcium ions and a calcium-influx blocker on basal and TRH- and GnRH-stimulated hormone release in patients with pituitary adenomas, Journal of Endocrinological Investigation, 10(5):427-33, October 1987 Abstract

  • Vance ML, Thorner MO, Prolactinomas, Endocrinology and Metabolism Clinics of North America, 16(3):731-53, September 1987 Abstract

  • Koritnik DR, Cronin MJ, Orth DN, Evans WS, Thorner MO, Pituitary response to intravenous hypothalamic releasing peptides in cynomolgus monkeys treated with contraceptive steroids, Journal of Clinical Endocrinology and Metabolism, 65(1):37-45, July 1987 Abstract

  • Mauras N, Blizzard RM, Thorner MO, Rogol AD, Selective beta 1-adrenergic receptor-blockade with atenolol enhances growth hormone releasing hormone and mediated growth hormone release in man, Metabolism: Clinical and Experimental, 36(4):369-72, April 1987 Abstract

  • Thorner MO, Hypothalamic releasing hormones: clinical possibilities, Hospital Practice (office Edition), 21(12):63-9, December 1986 Abstract

  • Zysk JR, Cronin MJ, Anderson JM, Thorner MO, Cross-linking of a growth hormone releasing factor-binding protein in anterior pituitary cells, Journal of Biological Chemistry, 261(36):16781-4, December 1986 Abstract

  • Vance ML, Evans WS, Kaiser DL, Burke RL, Rivier J, Vale W, Thorner MO, The effect of intravenous, subcutaneous, and intranasal GH-RH analog, [Nle27]GHRH(1-29)-NH2, on growth hormone secretion in normal men: dose-response relationships, Clinical Pharmacology and Therapeutics, 40(6):627-33, December 1986 Abstract

  • Vance ML, Thorner MO, Growth-hormone-releasing hormone: a clinical update, Annals of Internal Medicine, 105(3):447-9, September 1986 Abstract

  • Krieg RJ Jr, Thorner MO, Evans WS, Sex differences in beta-adrenergic stimulation of growth hormone secretion in vitro, Endocrinology, 119(3):1339-42, September 1986 Abstract

  • Hughes JM, Hichens M, Booze GW, Thorner MO, Cushing's syndrome from the therapeutic use of intramuscular dexamethasone acetate, Archives of Internal Medicine, 146(9):1848-9, September 1986 Abstract

  • Chalew SA, Armour KM, Levin PA, Thorner MO, Kowarski AA, Growth hormone (GH) response to GH-releasing hormone in children with subnormal integrated concentrations of GH, Journal of Clinical Endocrinology and Metabolism, 62(6):1110-5, June 1986 Abstract

  • Vance ML, Kaiser DL, Rivier J, Vale W, Thorner MO, Dual effects of growth hormone (GH)-releasing hormone infusion in normal men: somatotroph desensitization and increase in releasable GH, Journal of Clinical Endocrinology and Metabolism, 62(3):591-4, March 1986 Abstract

  • Evans WS, Vance ML, Kaiser DL, Sellers RP, Borges JL, Downs TR, Frohman LA, Rivier J, Vale W, Thorner MO, Effects of intravenous, subcutaneous, and intranasal administration of growth hormone (GH)-releasing hormone-40 on serum GH concentrations in normal men, Journal of Clinical Endocrinology and Metabolism, 61(5):846-50, November 1985 Abstract

  • Evans WS, Brannagan TH, Limber ER, Cronin MJ, Rogol AD, Hewlett EL, Thorner MO, Differential effects of forskolin on LH and GH release, American Journal of Physiology, 249(4 Pt 1):E392-7, October 1985 Abstract

  • Vance ML, Ridgway EC, Thorner MO, Follicle-stimulating hormone- and alpha-subunit-secreting pituitary tumor treated with bromocriptine, Journal of Clinical Endocrinology and Metabolism, 61(3):580-4, September 1985 Abstract

  • Williams T, Maxon H, Thorner MO, Frohman LA, Blunted growth hormone (GH) response to GH-releasing hormone in hypothyroidism resolves in the euthyroid state, Journal of Clinical Endocrinology and Metabolism, 61(3):454-6, September 1985 Abstract

  • Vance ML, Kaiser DL, Evans WS, Furlanetto R, Vale W, Rivier J, Thorner MO, Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). Evidence for intermittent somatostatin secretion, Journal of Clinical Investigation, 75(5):1584-90, May 1985 Abstract

  • Sheldon WR Jr, DeBold CR, Evans WS, DeCherney GS, Jackson RV, Island DP, Thorner MO, Orth DN, Rapid sequential intravenous administration of four hypothalamic releasing hormones as a combined anterior pituitary function test in normal subjects, Journal of Clinical Endocrinology and Metabolism, 60(4):623-30, April 1985 Abstract

  • Molitch ME, Elton RL, Blackwell RE, Caldwell B, Chang RJ, Jaffe R, Joplin G, Robbins RJ, Tyson J, Thorner MO, Bromocriptine as primary therapy for prolactin-secreting macroadenomas: results of a prospective multicenter study, Journal of Clinical Endocrinology and Metabolism, 60(4):698-705, April 1985 Abstract

  • Asa SL, Kovacs K, Thorner MO, Leong DA, Rivier J, Vale W, Immunohistological localization of growth hormone-releasing hormone in human tumors, Journal of Clinical Endocrinology and Metabolism, 60(3):423-7, March 1985 Abstract

  • Ho KY, Evans WS, Thorner MO, Disorders of prolactin and growth hormone secretion, Clinics in Endocrinology and Metabolism, 14(1):1-32, February 1985 Abstract

  • Evans WS, Borges JL, Vance ML, Kaiser DL, Rogol AD, Furlanetto R, Rivier J, Vale W, Thorner MO, Effects of human pancreatic growth hormone-releasing factor-40 on serum growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and somatomedin-C concentrations in normal women t, Journal of Clinical Endocrinology and Metabolism, 59(5):1006-10, November 1984 Abstract

  • Veldhuis JD, Evans WS, Rogol AD, Drake CR, Thorner MO, Merriam GR, Johnson ML, Intensified rates of venous sampling unmask the presence of spontaneous, high-frequency pulsations of luteinizing hormone in man, Journal of Clinical Endocrinology and Metabolism, 59(1):96-102, July 1984 Abstract

  • Carey RM, Varma SK, Drake CR Jr, Thorner MO, Kovacs K, Rivier J, Vale W, Ectopic secretion of corticotropin-releasing factor as a cause of Cushing's syndrome. A clinical, morphologic, and biochemical study, New England Journal of Medicine, 311(1):13-20, July 1984 Abstract

  • Cronin MJ, Evans WS, Thorner MO, One minute of bromocriptine irreversibly inhibits prolactin release for hours, European Journal of Pharmacology, 99(1):85-90, March 1984 Abstract

  • Cronin MJ, Hewlett EL, Evans WS, Thorner MO, Rogol AD, Human pancreatic tumor growth hormone (GH) - releasing factor and cyclic adenosine 3',5'- monophosphate evoke GH release from anterior pituitary cells: the effects of pertussis toxin, cholera toxin, f, Endocrinology, 114(3):904-13, March 1984 Abstract

  • Murray IC, McComb DJ, Hellmann P, Kovacs K, Thorner MO, The effect of bromocriptine on the mammary glands of hyperprolactinemic rats. A histologic, ultrastructural and morphometric study, Experimental Pathology, 26(3):131-40, 1984 Abstract

  • Login IS, Thorner MO, MacLeod RM, Zinc may have a physiological role in regulating pituitary prolactin secretion, Neuroendocrinology, 37(5):317-20, November 1983 Abstract

  • Borges JL, Blizzard RM, Gelato MC, Furlanetto R, Rogol AD, Evans WS, Vance ML, Kaiser DL, MacLeod RM, Merriam GR, Loriaux DL, Spiess J, Rivier J, Vale W, Thorner MO, Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency, Lancet, 2(8342):119-24, July 1983 Abstract

  • Login IS, Krieg RJ, Kaiser DL, Thorner MO, MacLeod RM, Unremitting suppression of the postovariectomy rise in plasma LH by tumor-induced hyperprolactinemia, Neuroendocrinology, 35(5):327-32, November 1982 Abstract

  • Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin M, Johanson A, Vale W, Horvath E, Kovacs K, Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor, Journal of Clinical Investigation, 70(5):965-77, November 1982 Abstract

  • Evans WS, Schiebinger RJ, Kaiser DL, Nunley WC Jr, Loriaux DL, MacLeod RM, Thorner MO, Serum adrenal androgens in hyperprolactinaemic women prior to, during, and after chronic treatment with bromocriptine, Acta Endocrinologica, 101(2):235-41, October 1982 Abstract

  • Thorner MO, A young man with visual defect and galactorrhea, Hospital Practice (office Edition), 17(8):122L 122P 122T passi, August 1982 Abstract

  • Cronin MJ, Rogol AD, Dabney LG, Thorner MO, Selective growth hormone and cyclic AMP stimulating activity is present in human pancreatic islet cell tumor, Journal of Clinical Endocrinology and Metabolism, 55(2):381-3, August 1982 Abstract

  • Borges JL, Kaiser DL, Evans WS, Thorner MO, A model system for the study of luteinizing hormone (LH) secretion: lack of effect of fetal calf serum on gonadotropin-releasing hormone stimulated LH release, Proceedings of the Society for Experimental Biology and Medicine, 170(1):82-88, May 1982 Abstract

  • Perryman RL, Rogol AD, Kaiser DL, MacLeod RM, Thorner MO, Pergolide mesylate: its effects on circulating anterior pituitary hormones in man, Journal of Clinical Endocrinology and Metabolism, 53(4):772-8, October 1981 Abstract

  • Thorner MO, Evans WS, MacLeod RM, Nunley WC Jr, Rogol AD, Morris JL, Besser GM, Hyperprolactinemia: current concepts of management including medical therapy with bromocriptine, Advances in Biochemical Psychopharmacology, 23, 165-89, 1980 Abstract

  • Edwards CR, Besser GM, Thorner MO, Bromocriptine-responsive form of idiopathic oedema [letter], Lancet, 2(8133):94, July 1979 Abstract

  • Wass JA, Moult PJ, Thorner MO, Dacie JE, Charlesworth M, Jones AE, Besser GM, Reduction of pituitary-tumour size in patients with prolactinomas and acromegaly treated with bromocriptine with or without radiotherapy, Lancet, 2(8133):66-9, July 1979 Abstract

  • Besser GM, Thorner MO, Wass JA, Doniach I, Canti G, Curling M, Grudziniskas JG, Setchell ME, Absence of uterine neoplasia in patients on bromocriptine, British Medical Journal, 2(6091):868, October 1977 Abstract

  • Thorner MO, Prolactin, Clinics in Endocrinology and Metabolism, 6(1):201-22, March 1977 Abstract

  • Evered DC, Gomez-Pan A, Tunbridge WM, Hall R, Lind T, Besser GM, Mortimer CH, Thorner MO, Schally AV, Kastin AJ, Coy DH, Letter: Analogues of growth-hormone release-inhibiting hormone, Lancet, 1(7918):1250, May 1975 Abstract

  • Besser GM, Mortimer CH, McNeilly AS, Thorner MO, Batistoni GA, Bloom SR, Kastrup KW, Hanssen KF, Hall R, Coy DH, Kastin AJ, Schally AV, Long-term infusion of growth hormone release inhibiting hormone in acromegaly: effects on pituitary and pancreatic hormones, British Medical Journal, 4(5945):622-7, December 1974 Abstract

  • Thorner MO, Bloom SR, Letter: Rapid glucagon release in artificial fever, Lancet, 2(7881):654, September 1974 Abstract

  • Landon J, Rees L, Thorner MO, Clinical biochemistry and endocrinology--the future, Annals of Clinical Biochemistry, 11(5):153-5, September 1974 Abstract

  • McNeilly AS, Thorner MO, Volans G, Besser GM, Letter: Metaclopramide and prolactin, British Medical Journal, 2(921):729, June 1974 Abstract

  • Silva CM, Lu H, Weber MJ, Thorner MO, Differential Thyrosine Phosphorlation of JAK1, JAK2 and Statl by Growth Hormone and Interferony in IM-9 Cells, Journal of Biological Chemistry, 44, 27532-27539
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