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William I. Bensinger

Fred Hutchinson Cancer Research Center
Clinical Research Division


University of Washington
School of Medicine
Medicine
Oncology
Associate Professor     Appointed: 1989
William I. Bensinger
Mailing Address
Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N., D5-390
P.O. Box 19024
Seattle, Washington 98109-1024
United States
Contact Information
Phone: (206) 667-4933
Fax: (206) 667-4937
wbensing@fhcrc.org
Qualifications
M.D., Northwestern University, 1973
Expertise and Research Interests
Autologous Program
The Autologous Stem Cell Transplant Program at the FHCRC is focused on combining improved high dose therapy regimens, peripheral blood stem cells (PBSC) and post transplant immunotherapies designed to increase the fraction of patientswith malignant disease who can be cured. Some of the more innovative treatment strategies developed in the Autologous program have been used to pilot new safer treatment programs developed at the FHCRC are validated through a cooperative, high dose therapy group comprised of smaller, transplant centers in the northwest. In addition, as noted below, some of the treatment strategies developed in the Autologous Program are sufficiently promising to foster new conditioning regimens for patients who can undergo allogeneic transplantation. Due to the success of PBSC in autograft patients, studies of allogeneic PBSC have been underway and have demonstrated significant benefit of PBSC over marrow.

Targeted Radiotherapy Studies
This project involves the use of a radiometal 166-Holmium, which is a high energy beta particle emitting isotope with a relatively short half-life (26 hours). The isotope is coupled to a bone-seeking chelate DOTMP. When given intravenously, 166-Ho-DOTMP is taken up almost exclusively into bone, with negligible uptake in liver, lung, kidneys or gastrointestinal tract. This irradiates all of the marrow bearing areas where the overwhelming bulk of myeloma cells reside. At the FHCRC, a total of 38 patients have received 20-40 Gy of 166-Ho-DOTMP with melphalan of melphalan + TBI. The major toxicities as expected were marrow ablation with minor extramedullary toxicities. No treatment related deaths have occurred at the FHCRC. Approximately 45% of the evaluable patients (25 patients evaluable so far) have achieved complete remissions of their myeloma. Based on these encouraging data a phase III randomized study comparing 166-Ho-DOTMP + melphalan versus melphalan as a preparative regimen for patients with myeloma is planned to begin this summer. This unique approach should allow the delivery of higher doses of radiation to sites of disease while avoiding the dose limiting toxicities of high dose therapy.

If successful, this strategy could be extended to other diseases such as prostate cancer and is currently being studied in Ewing’s sarcoma and breast cancer. The treatment may also serve as a platform for the so named mini-transplants which use less intensive conditioning prior to allogeneic stem cell transplantation in order to avoid the relatively high transplant related mortality occuring after standard allografting. A protocol designed to provided targeted radiotherapy with 166-Ho-DOTMP in combination with allogeneic transplants is underway.

Immunotherapy Studies
Promising studies utilizing interleukin-2 (IL-2) and GM-CSF are being investigated by Dr. Leona Holmberg. In an ongoing trial, autologous peripheral blood stem cells are thawed and incubated for 24 hours with IL-2 prior to transplant into recipients with breast canceror lymphoma. Lymphokine activated killer cell (LAK) cell and natural killer (NK) cell activity is greatly enhanced by this approach. Patients receive low dose IL-2 subcutaneously for up to 4 weeks following stem cell infusion. The treatment has been well tolerated and engraftment has been rapid in all patients. This approach appears to have significant activity in patients with chemotherapy-resistant breast cancer.

In a similar trial, 10 patients with multiple myeloma have received high-dose chemotherapy followed by IL-2 incubated PBSC and low dose IL-2 for 4 weeks. The treatment was well tolerated and all patients are surviving 1 to 4 years from transplant. Only 2 relapses have occurred. Additional studies are underway in patients with lymphomaand CML.
Keywords
COS Keywords: Bone Marrow Transplantation; Breast Cancer; Cancer Biology; Immunotherapy; Oncology; Radiotherapy; Stem Cells
Publications
  • Flowers ME, Parker PM, Johnston LJ, Matos AV, Storer B, Bensinger WI, Storb R, Appelbaum FR, Forman SJ, Blume KG, Martin PJ, Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long-term follow-up of a randomized trial, Blood, 100(2):415-9, July 2002 Abstract

  • Bensinger WI, Allogeneic hematopoietic cell transplantation for multiple myeloma, Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 56(3):133-8, May 2002 Abstract

  • Weissinger F, Sandmaier BM, Maloney DG, Bensinger WI, Gooley T, Storb R, Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings, Blood, 98(13):3584-8, December 2001 Abstract

  • Zaucha JM, Gooley T, Bensinger WI, Heimfeld S, CD34 cell dose in granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cell grafts affects engraftment kinetics and development extensive chronic graft-versus-host disease afte, Blood, 98(12):3221-7, December 2001 Abstract

  • Rowley SD, Yu J, Gooley T, Heimfeld S, Holmberg L, Maloney D, Bensinger WI, Trafficking of CD34+ cells into the peripheral circulation during collection of peripheral blood stem cells by apheresis, Bone Marrow Transplantation, 28(7):649-56, October 2001 Abstract

  • Gutierrez-Delgado F, Maloney DG, Press OW, Golden J, Holmberg LA, Maziarz RT, Hooper H, Buckner CD, Appelbaum FR, Bensinger WI, Autologous stem cell transplantation for non-Hodgkin's lymphoma: comparison of radiation-based and chemotherapy-only preparative regimens, Bone Marrow Transplantation, 28(5):455-61, September 2001 Abstract

  • Bensinger WI, Maloney D, Storb R, Allogeneic hematopoietic cell transplantation for multiple myeloma, Seminars in Hematology, 38(3):243-9, July 2001 Abstract

  • Bensinger WI, Storb R, Allogeneic peripheral blood stem cell transplantation, Reviews in Clinical and Experimental Hematology, 5(2):67-86, June 2001 Abstract

  • McSweeney PA, Niederwieser D, Shizuru JA, Sandmaier BM, Molina AJ, Maloney DG, Chauncey TR, Gooley TA, Hegenbart U, Nash RA, Radich J, Wagner JL, Minor S, Appelbaum FR, Bensinger WI, Bryant E, Flowers ME, Georges GE, Grumet FC, Kiem HP, Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects, Blood, 97(11):3390-400, June 2001 Abstract

  • Rowley SD, Donaldson G, Lilleby K, Bensinger WI, Appelbaum FR, Experiences of donors enrolled in a randomized study of allogeneic bone marrow or peripheral blood stem cell transplantation, Blood, 97(9):2541-8, May 2001 Abstract

  • Al-Ghamdi H, Leisenring W, Bensinger WI, Nash RA, Storb R, Appelbaum FR, Martin PJ, A proposed objective way to assess results of randomized prospective clinical trials with acute graft-versus-host disease as an outcome of interest, British Journal of Haematology, 113(2):461-9, May 2001 Abstract

  • Gopal AK, Gooley TA, Golden JB, Maloney DG, Bensinger WI, Petersdorf SH, Appelbaum FR, Press OW, Efficacy of high-dose therapy and autologous hematopoietic stem cell transplantation for non-Hodgkin's lymphoma in adults 60 years of age and older, Bone Marrow Transplantation, 27(6):593-9, March 2001 Abstract

  • Bensinger WI, Martin PJ, Storer B, Clift R, Forman SJ, Negrin R, Kashyap A, Flowers ME, Lilleby K, Chauncey TR, Storb R, Appelbaum FR, Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers, The New England Journal of Medicine, 344(3):175-81, Jan 2001 Abstract

  • Bruno B, Gooley T, Sullivan KM, Davis C, Bensinger WI, Storb R, Nash RA, Secondary failure of platelet recovery after hematopoietic stem cell transplantation, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 7(3):154-62, 2001 Abstract

  • Bensinger WI, E. Donnall Thomas, M.D., Nobel Laureate in medicine, Journal of Hematotherapy and Stem Cell Research, 9(4):401-2, August 2000 Abstract

  • Chauncey TR, Gooley TA, Lloid ME, Schubert MM, Lilleby K, Holmberg L, Bensinger WI, Pilot trial of cytoprotection with amifostine given with high-dose chemotherapy and autologous peripheral blood stem cell transplantation, American Journal of Clinical Oncology : the Official Publication of the American Radium Society, 23(4):406-11, August 2000 Abstract

  • Gutierrez-Delgado F, Holmberg LA, Hooper H, Appelbaum FR, Livingston RB, Maziarz RT, Weiden P, Rivkin S, Montgomery P, Kawahara K, Bensinger W, High-dose busulfan, melphalan and thiotepa as consolidation for non-inflammatory high-risk breast cancer, Bone Marrow Transplantation, 26(1):51-9, July 2000 Abstract

  • Saunders MD, Shulman HM, Murakami CS, Chauncey TR, Bensinger WI, McDonald GB, Bile duct apoptosis and cholestasis resembling acute graft-versus-host disease after autologous hematopoietic cell transplantation, The American Journal of Surgical Pathology, 24(7):1004-8, July 2000 Abstract

  • Holmberg LA, Oparin DV, Gooley T, Lilleby K, Bensinger W, Reddish MA, MacLean GD, Longenecker BM, Sandmaier BM, Clinical outcome of breast and ovarian cancer patients treated with high-dose chemotherapy, autologous stem cell rescue and THERATOPE STn-KLH cancer vaccine, Bone Marrow Transplantation, 25(12):1233-41, June 2000 Abstract

  • Yu J, Leisenring W, Fritschle W, Heimfeld S, Shulman H, Bensinger WI, Holmberg LA, Rowley SD, Enumeration of HPC in mobilized peripheral blood with the Sysmex SE9500 predicts final CD34+ cell yield in the apheresis collection, Bone Marrow Transplantation, 25(11):1157-64, June 2000 Abstract

  • Bensinger WI, Deeg HJ, Blood or marrow?, Lancet, 355(9211):1199-200, April 2000 Abstract

  • Cavallaro AM, Lilleby K, Majolino I, Storb R, Appelbaum FR, Rowley SD, Bensinger WI, Three to six year follow-up of normal donors who received recombinant human granulocyte colony-stimulating factor, Bone Marrow Transplantation, 25(1):85-9, Jan 2000 Abstract

  • Holmberg LA, Boeckh M, Hooper H, Leisenring W, Rowley S, Heimfeld S, Press O, Maloney DG, McSweeney P, Corey L, Maziarz RT, Appelbaum FR, Bensinger W, Increased incidence of cytomegalovirus disease after autologous CD34-selected peripheral blood stem cell transplantation, Blood, 94(12):4029-35, 1999 Abstract

  • Yu J, Leisenring W, Bensinger WI, Holmberg LA, Rowley SD, The predictive value of white cell or CD34+ cell count in the peripheral blood for timing apheresis and maximizing yield., Transfusion, 39(5):442-50, May 1999 Abstract

  • Holmberg LA, Demirer T, Rowley S, Buckner CD, Goodman G, Maziarz R, Klarnet J, Zuckerman N, Harrer G, McCloskey R, Gersh R, Goldberg R, Nichols W, Jacobs A, Weiden P, Montgomery P, Rivkin S, Appelbaum FR, Bensinger WI, High-dose busulfan, melphalan and thiotepa followed by autologous peripheral blood stem cell \(PBSC\) rescue in patients with advanced stage III/IV ovarian cancer., Bone Marrow Transplantation, 22(7):651-9, October 1998 Abstract

  • Rowley S D, Loken M, Radich J, Kunkle L A, Mills B J, Gooley T, Holmberg L, McSweeney P, Beach K, MacLeod B, Appelbaum F, Bensinger W I, Isolation of CD34+ cells from blood stem cell components using the Baxter Isolex system., Bone Marrow Transplantation, 21(12):1253-62, June 1998 Abstract

  • Bensinger W I, Should we purge? [editorial; comment], Bone Marrow Transplantation, 21(2):113-5, Jan 1998 Abstract

  • Williams O, Demirer T, Lilleby K, Buckner C D, Bensinger W I, Tempo of hematologic recovery correlates with peripheral blood CD34+ cell level in patients undergoing stem cell mobilization., Journal of Clinical Apheresis, 13(1):1-6, 1998 Abstract

  • Storek J, Gooley T, Siadak M, Bensinger W I, Maloney D G, Chauncey T R, Flowers M, Sullivan K M, Witherspoon R P, Rowley S D, Hansen J A, Storb R, Appelbaum F R, Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease., Blood, 90(12):4705-9, 15 Dec 1997 Abstract

  • Fefer A, Robinson N, Benyunes M C, Bensinger W I, Press O, Thompson J A, Lindgren C, Interleukin-2 therapy after bone marrow or stem cell transplantation for hematologic malignancies, Cancer Journal From Scientific American, 3 Suppl 1, S48-53, December 1997 Abstract

  • Schiffman K, Buckner C D, Maziarz R, Maloney D G, Appelbaum F R, Press O, Gooley T, Holmberg L, Lilleby K, Clift R, Zuckerman N, Klarnet J, Weaver C, Chauncey T, Bensinger W I, High-dose busulfan, melphalan, and thiotepa followed by autologous peripheral blood stem cell transplantation in patients with aggressive lymphoma or relapsed Hodgkin's disease., Biology of Blood and Marrow Transplantation, 3(5):261-6, November 1997 Abstract

  • Storb R, Leisenring W, Anasetti C, Appelbaum F R, Deeg H J, Doney K, Martin P, Sullivan K M, Witherspoon R, Pettinger M, Bensinger W, Buckner C D, Clift R, Flowers M E, Hansen J A, Pepe M, Chauncey T, Sanders J, Thomas E D, Methotrexate and cyclosporine for graft-vs.-host disease prevention: what length of therapy with cyclosporine?, Biology of Blood and Marrow Transplantation, 3(4):194-201, October 1997 Abstract

  • Bensinger W I, Schiffman K S, Holmberg L, Appelbaum F R, Maziarz R, Montgomery P, Ellis E, Rivkin S, Weiden P, Lilleby K, Rowley S, Petersdorf S, Klarnet J P, Nichols W, Hertler A, McCroskey R, Weaver C H, Buckner C D, High-dose busulfan, melphalan, thiotepa and peripheral blood stem cell infusion for the treatment of metastatic breast cancer., Bone Marrow Transplantation, 19(12):1183-9, June 1997 Abstract

  • Storb R, Leisenring W, Anasetti C, Appelbaum F R, Buckner C D, Bensinger W I, Chauncey T, Clift R A, Deeg H J, Doney K C, Flowers M E, Hansen J A, Martin P J, Sanders J E, Sullivan K M, Witherspoon R P, Long-term follow-up of allogeneic marrow transplants in patients with aplastic anemia conditioned by cyclophosphamide combined with antithymocyte globulin, Blood, 89(10):3890-1, 15 May 1997 Abstract

  • Slattery J T, Clift R A, Buckner C D, Radich J, Storer B, Bensinger W I, Soll E, Anasetti C, Bowden R, Bryant E, Chauncey T, Deeg H J, Doney K C, Flowers M, Gooley T, Hansen J A, Martin P J, McDonald G B, Nash R, Petersdorf E W, Sanders J E, Schoch G, Stewart P, Storb R, Appelba, Marrow transplantation for chronic myeloid leukemia: the influence of plasma busulfan levels on the outcome of transplantation., Blood, 89(8):3055-60, 15 Apr 1997 Abstract

  • Anderson J E, Gooley T A, Schoch G, Anasetti C, Bensinger W I, Clift R A, Hansen J A, Sanders J E, Storb R, Appelbaum F R, Stem cell transplantation for secondary acute myeloid leukemia: evaluation of transplantation as initial therapy or following induction chemotherapy., Blood, 89(7):2578-85, 1 Apr 1997 Abstract

  • Buckner C D, Bensinger W I, Allogeneic peripheral blood stem cell transplantation., Rinsho ketsueki. Japanese Journal of Clinical Hematology, 38(3):157-61, March 1997 Abstract

  • Robinson N, Benyunes M C, Thompson J A, York A, Petersdorf S, Press O, Lindgren C, Chauncey T, Buckner C D, Bensinger W I, Appelbaum F R, Fefer A, Interleukin-2 after autologous stem cell transplantation for hematologic malignancy: a phase I/II study., Bone Marrow Transplantation, 19(5):435-42, March 1997 Abstract

  • Bensinger W I, Buckner D, Gahrton G, Allogeneic stem cell transplantation for multiple myeloma., hematology/oncology Clinics of North America, 11(1):147-57, February 1997 Abstract

  • Demirer T, Buckner C D, Storer B, Lilleby K, Rowley S, Clift R, Appelbaum F R, Storb R, Bensinger W I, Effect of different chemotherapy regimens on peripheral-blood stem-cell collections in patients with breast cancer receiving granulocyte colony-stimulating factor., Journal of Clinical Oncology, 15(2):684-90, February 1997 Abstract

  • Bensinger W I, Buckner C D, Shannon-Dorcy K, Rowley S, Appelbaum F R, Benyunes M, Clift R, Martin P, Demirer T, Storb R, Lee M, Schiller G, Transplantation of allogeneic CD34+ peripheral blood stem cells in patients with advanced hematologic malignancy., Blood, 88(11):4132-8, 1 Dec 1996 Abstract

  • Bensinger W I, Clift R, Martin P, Appelbaum F R, Demirer T, Gooley T, Lilleby K, Rowley S, Sanders J, Storb R, Buckner C D, Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation., Blood, 88(7):2794-800, 1 Oct 1996 Abstract

  • Bensinger W I, Buckner C D, Anasetti C, Clift R, Storb R, Barnett T, Chauncey T, Shulman H, Appelbaum F R, Allogeneic marrow transplantation for multiple myeloma: an analysis of risk factors on outcome., Blood, 88(7):2787-93, 1 Oct 1996 Abstract

  • Bensinger W I, Demirer T, Buckner C D, Appelbaum F R, Storb R, Lilleby K, Weiden P, Bluming A Z, Fefer A, Syngeneic marrow transplantation in patients with multiple myeloma., Bone Marrow Transplantation, 18(3):527-31, September 1996 Abstract

  • McSweeney P A, Wells D A, Shults K E, Nash R A, Bensinger W I, Buckner C D, Loken M R, Tumor-specific aneuploidy not detected in CD19+ B-lymphoid cells from myeloma patients in a multidimensional flow cytometric analysis., Blood, 88(2):622-32, 15 Jul 1996 Abstract

  • Brunvand M W, Bensinger W I, Soll E, Weaver C H, Rowley S D, Appelbaum F R, Lilleby K, Clift R A, Gooley T A, Press O W, Fefer A, Storb R, Sanders J E, Martin P L, Chauncey T, Maziarz R T, Zuckerman N, Montgomery P, Dorn R, Weiden P L, Demirer T, Holmberg L A, Schiffman K, McSw, High-dose fractionated total-body irradiation, etoposide and cyclophosphamide for treatment of malignant lymphoma: comparison of autologous bone marrow and peripheral blood stem cells., Bone Marrow Transplantation, 18(1):131-41, July 1996 Abstract

  • Demirer T, Petersen F B, Bensinger W I, Appelbaum F R, Fefer A, Rowley S, Sanders J, Chauncey T, Storb R, Lilleby K, Buckner C D, Autologous transplantation with peripheral blood stem cells collected after granulocyte colony-stimulating factor in patients with acute myelogenous leukemia., Bone Marrow Transplantation, 18(1):29-34, July 1996 Abstract

  • Schiffman K S, Bensinger W I, Appelbaum F R, Rowley S, Lilleby K, Clift R A, Weaver C H, Demirer T, Sanders J E, Petersdorf S, Gooley T, Weiden P, Zuckerman N, Montgomery P, Maziarz R, Klarnet J P, Rivkin S, Trueblood K, Storb R, Holmberg L, Buckner C D, Phase II study of high-dose busulfan, melphalan and thiotepa with autologous peripheral blood stem cell support in patients with malignant disease., Bone Marrow Transplantation, 17(6):943-50, June 1996 Abstract

  • Demirer T, Buckner C D, Gooley T, Appelbaum F R, Rowley S, Chauncey T, Lilleby K, Storb R, Bensinger W I, Factors influencing collection of peripheral blood stem cells in patients with multiple myeloma., Bone Marrow Transplantation, 17(6):937-41, June 1996 Abstract

  • Demirer T, Buckner C D, Appelbaum F R, Clift R, Storb R, Myerson D, Lilleby K, Rowley S, Bensinger W I, High-dose busulfan and cyclophosphamide followed by autologous transplantation in patients with advanced breast cancer., Bone Marrow Transplantation, 17(5):769-74, May 1996 Abstract

  • Attarian H, Bensinger W I, Buckner C D, McDonald D L, Rowley S D, Microbial contamination of peripheral blood stem cell collections., Bone Marrow Transplantation, 17(5):699-702, May 1996 Abstract

  • Slattery J T, Kalhorn T F, McDonald G B, Lambert K, Buckner C D, Bensinger W I, Anasetti C, Appelbaum F R, Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients., Journal of Clinical Oncology, 14(5):1484-94, May 1996 Abstract

  • Bensinger W I, Rowley S D, Demirer T, Lilleby K, Schiffman K, Clift R A, Appelbaum F R, Fefer A, Barnett T, Storb R, Chauncey T, Maziarz R T, Klarnet J, McSweeney P, Holmberg L, Maloney D G, Weaver C H, Buckner C D, High-dose therapy followed by autologous hematopoietic stem-cell infusion for patients with multiple myeloma., Journal of Clinical Oncology, 14(5):1447-56, May 1996 Abstract

  • Demirer T, Buckner C D, Appelbaum F R, Bensinger W I, Sanders J, Lambert K, Clift R, Fefer A, Storb R, Slattery J T, Busulfan, cyclophosphamide and fractionated total body irradiation for autologous or syngeneic marrow transplantation for acute and chronic myelogenous leukemia: phase I dose escalation of busulfan ba, Bone Marrow Transplantation, 17(4):491-5, April 1996 Abstract

  • Bensinger W I, Buckner C D, Demirer T, Storb R, Appelbaum F A, Transplantation of allogeneic peripheral blood stem cells., Bone Marrow Transplantation, 17 Suppl 2, S56-7, March 1996 Abstract

  • Bensinger W I, Buckner C D, Rowley S, Demirer T, Storb R, Appelbaum F A, Transplantation of allogeneic CD34+ peripheral blood stem cells (PBSC) in patients with advanced hematologic malignancy., Bone Marrow Transplantation, 17 Suppl 2, S38-9, March 1996 Abstract

  • Bensinger W I, Buckner C D, Rowley S, Storb R, Appelbaum F R, Treatment of normal donors with recombinant growth factors for transplantation of allogeneic blood stem cells., Bone Marrow Transplantation, 17 Suppl 2, S19-21, March 1996 Abstract

  • Demirer T, Buckner C D, Appelbaum F R, Lambert K, Bensinger W I, Clift R, Storb R, Slattery J T, Busulfan, cyclophosphamide and fractionated total body irradiation for allogeneic marrow transplantation in advanced acute and chronic myelogenous leukemia: phase I dose escalation of busulfan based o, Bone Marrow Transplantation, 17(3):341-6, March 1996 Abstract

  • Demirer T, Buckner C D, Bensinger W I, Optimization of peripheral blood stem cell mobilization., Stem Cells, 14(1):106-16, January 1996 Abstract

  • Bensinger W I, Clift R A, Anasetti C, Appelbaum F A, Demirer T, Rowley S, Sandmaier B M, Torok-Storb B, Storb R, Buckner C D, Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony stimulating factor., Stem Cells, 14(1):90-105, January 1996 Abstract

  • Anderson J E, Appelbaum F R, Schoch G, Gooley T, Anasetti C, Bensinger W I, Bryant E, Buckner C D, Chauncey T, Clift R A, et al, Allogeneic marrow transplantation for myelodysplastic syndrome with advanced disease morphology: a phase II study of busulfan, cyclophosphamide, and total-body irradiation and analysis of prognostic f, Journal of Clinical Oncology, 14(1):220-6, January 1996 Abstract

  • Anderson J E, Appelbaum F R, Schoch G, Gooley T, Anasetti C, Bensinger W I, Bryant E, Buckner C D, Chauncey T R, Clift R A, Doney K, Flowers M, Hansen J A, Martin P J, Matthews D C, Sanders J E, Shulman H, Sullivan K M, Witherspoon R P, Storb R, Allogeneic marrow transplantation for refractory anemia: a comparison of two preparative regimens and analysis of prognostic factors., Blood, 87(1):51-8, 1 Jan 1996 Abstract

  • Bensinger W I, Appelbaum F A, Demirer T, Torok-Storb B, Storb R, Buckner C D, Transplantation of allogeneic peripheral blood stem cells., Stem Cells, 13 Suppl 3, 63-70, December 1995 Abstract

  • Bensinger W, Appelbaum F, Rowley S, Storb R, Sanders J, Lilleby K, Gooley T, Demirer T, Schiffman K, Weaver C, et al, Factors that influence collection and engraftment of autologous peripheral-blood stem cells., Journal of Clinical Oncology, 13(10):2547-55, October 1995 Abstract

  • Demirer T, Petersen F B, Appelbaum F R, Barnett T A, Sanders J, Deeg H J, Storb R, Doney K, Bensinger W I, Shannon-Dorcy K, et al, Allogeneic marrow transplantation following cyclophosphamide and escalating doses of hyperfractionated total body irradiation in patients with advanced lymphoid malignancies: a Phase I/II trial., International Journal of Radiation Oncology, Biology, Physics, 32(4):1103-9, 15 Jul 1995 Abstract

  • Slattery J T, Sanders J E, Buckner C D, Schaffer R L, Lambert K W, Langer F P, Anasetti C, Bensinger W I, Fisher L D, Appelbaum F R, et al, Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics [published erratum appears in Bone Marrow Transplant 1996 Oct;18(4):829], Bone Marrow Transplantation, 16(1):31-42, July 1995 Abstract

  • Demirer T, Rowley S, Buckner C D, Appelbaum F R, Lilleby K, Storb R, Schiffman K, Bensinger W I, Peripheral-blood stem-cell collections after paclitaxel, cyclophosphamide, and recombinant human granulocyte colony-stimulating factor in patients with breast and ovarian cancer., Journal of Clinical Oncology, 13(7):1714-9, July 1995 Abstract

  • Demirer T, Gooley T, Buckner C D, Petersen F B, Lilleby K, Rowley S, Sanders J, Storb R, Appelbaum F R, Bensinger W I, Influence of total nucleated cell dose from marrow harvests on outcome in patients with acute myelogenous leukemia undergoing autologous transplantation., Bone Marrow Transplantation, 15(6):907-13, June 1995 Abstract

  • Demirer T, Bensinger W I, Optimization of peripheral blood stem cell collection., Current Opinion In Hematology, 2(3):219-26, May 1995 Abstract

  • Kwak L W, Taub D D, Duffey P L, Bensinger W I, Bryant E M, Reynolds C W, Longo D L, Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor., Lancet, 345(8956):1016-20, 22 Apr 1995 Abstract

  • Bensinger W I, Weaver C H, Appelbaum F R, Rowley S, Demirer T, Sanders J, Storb R, Buckner C D, Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor [see comments], Blood, 85(6):1655-8, 15 Mar 1995 Abstract

  • Demirer T, Weaver C H, Buckner C D, Petersen F B, Bensinger W I, Sanders J, Clift R A, Lilleby K, Anasetti C, Martin P, et al, High-dose cyclophosphamide, carmustine, and etoposide followed by allogeneic bone marrow transplantation in patients with lymphoid malignancies who had received prior dose-limiting radiation therapy., Journal of Clinical Oncology, 13(3):596-602, March 1995 Abstract

  • Langenmayer I, Weaver C, Buckner C D, Lilleby K, Appelbaum F R, Longin K, Rowley S, Storb R, Singer J, Bensinger W I, Engraftment of patients with lymphoid malignancies transplanted with autologous bone marrow, peripheral blood stem cells or both., Bone Marrow Transplantation, 15(2):241-6, February 1995 Abstract

  • Lynch M H, Petersen F B, Appelbaum F R, Bensinger W I, Clift R A, Storb R, Sanders J E, Hansen J A, Buckner C D, Phase II study of busulfan, cyclophosphamide and fractionated total body irradiation as a preparatory regimen for allogeneic bone marrow transplantation in patients with advanced myeloid malignancies., Bone Marrow Transplantation, 15(1):59-64, January 1995 Abstract

  • Bensinger W, Peripheral blood stem cell transplantation., Cancer Treatment and Research, 76, 169-93, 1995 Abstract

  • Clift R A, Buckner C D, Thomas E D, Bryant E, Anasetti C, Bensinger W I, Bowden R, Deeg H J, Doney K C, Fisher L D, et al, Marrow transplantation for patients in accelerated phase of chronic myeloid leukemia., Blood, 84(12):4368-73, 15 Dec 1994 Abstract

  • Weaver C H, Petersen F B, Appelbaum F R, Bensinger W I, Press O, Martin P, Sandmaier B, Deeg H J, Hansen J A, Brunvand M, et al, High-dose fractionated total-body irradiation, etoposide, and cyclophosphamide followed by autologous stem-cell support in patients with malignant lymphoma., Journal of Clinical Oncology, 12(12):2559-66, December 1994 Abstract

  • Weaver C H, Clift R A, Deeg H J, Storb R, Appelbaum F R, Bensinger W, Doney K, Hansen J A, Martin P O, Sanders J, et al, Effect of graft-versus-host disease prophylaxis on relapse in patients transplanted for acute myeloid leukemia., Bone Marrow Transplantation, 14(6):885-93, December 1994 Abstract

  • Schuening F, Miller A D, Torok-Storb B, Bensinger W, Storb R, Reynolds T, Fisher L, Buckner C D, Appelbaum F R, Study on contribution of genetically marked peripheral blood repopulating cells to hematopoietic reconstitution after transplantation., Human Gene Therapy, 5(12):1523-34, December 1994 Abstract

  • Weaver C H, Bensinger W I, Appelbaum F R, Lilleby K, Sandmaier B, Brunvand M, Rowley S, Petersdorf S, Rivkin S, Gooley T, et al, Phase I study of high-dose busulfan, melphalan and thiotepa with autologous stem cell support in patients with refractory malignancies., Bone Marrow Transplantation, 14(5):813-9, November 1994 Abstract

  • Clift R A, Buckner C D, Thomas E D, Bensinger W I, Bowden R, Bryant E, Deeg H J, Doney K C, Fisher L D, Hansen J A, et al, Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide., Blood, 84(6):2036-43, 15 Sep 1994 Abstract

  • Bensinger W I, Longin K, Appelbaum F, Rowley S, Weaver C, Lilleby K, Gooley T, Lynch M, Higano T, Klarnet J, et al, Peripheral blood stem cells (PBSCs) collected after recombinant granulocyte colony stimulating factor (rhG-CSF): an analysis of factors correlating with the tempo of engraftment after transplantation, British Journal of Haematology, 87(4):825-31, August 1994 Abstract

  • Storb R, Etzioni R, Anasetti C, Appelbaum F R, Buckner C D, Bensinger W, Bryant E, Clift R, Deeg H J, Doney K, et al, Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia., Blood, 84(3):941-9, 1 Aug 1994 Abstract

  • Demirer T, Buckner C D, Lilleby K, Weaver C, Longin K, Appelbaum F R, Bensinger W I, Failure of a single cycle of high dose cyclophosphamide followed by intensive myeloablative therapy and autologous stem cell transplantation to improve outcome in relapsed disease., Cancer, 74(2):715-21, 15 Jul 1994 Abstract

  • Rowley S D, Bensinger W I, Gooley T A, Buckner C D, Effect of cell concentration on bone marrow and peripheral blood stem cell cryopreservation., Blood, 83(9):2731-6, 1 May 1994 Abstract

  • Storb R, Leisenring W, Deeg H J, Anasetti C, Appelbaum F, Bensinger W, Buckner C D, Clift R, Doney K, Hansen J, et al, Long-term follow-up of a randomized trial of graft-versus-host disease prevention by methotrexate/cyclosporine versus methotrexate alone in patients given marrow grafts for severe aplastic anemia, Blood, 83(9):2749-50, 1 May 1994 Abstract

  • Weaver C H, Longin K, Buckner C D, Bensinger W, Lymphocyte content in peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony-stimulating factor., Bone Marrow Transplantation, 13(4):411-5, April 1994 Abstract

  • Neubauer M A, Benyunes M C, Thompson J A, Bensinger W I, Lindgren C G, Buckner C D, Fefer A, Lymphokine-activated killer (LAK) precursor cell activity is present in infused peripheral blood stem cells and in the blood after autologous peripheral blood stem cell transplantation., Bone Marrow Transplantation, 13(3):311-6, March 1994 Abstract

  • Clift R A, Bianco J A, Appelbaum F R, Buckner C D, Singer J W, Bakke L, Bensinger W I, Bowden R A, McDonald G B, Schubert M, et al, A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation., Blood, 82(7):2025-30, 1 Oct 1993 Abstract

  • Doney K, Buckner C D, Fisher L, Petersen F B, Sanders J, Appelbaum F R, Anasetti C, Badger C, Bensinger W, Deeg H J, et al, Autologous bone marrow transplantation for acute lymphoblastic leukemia., Bone Marrow Transplantation, 12(4):315-21, October 1993 Abstract

  • Weaver C H, Buckner C D, Longin K, Appelbaum F R, Rowley S, Lilleby K, Miser J, Storb R, Hansen J A, Bensinger W, Syngeneic transplantation with peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony-stimulating factor., Blood, 82(7):1981-4, 1 Oct 1993 Abstract

  • Anderson J E, Appelbaum F R, Fisher L D, Schoch G, Shulman H, Anasetti C, Bensinger W I, Bryant E, Buckner C D, Doney K, et al, Allogeneic bone marrow transplantation for 93 patients with myelodysplastic syndrome., Blood, 82(2):677-81, 15 Jul 1993 Abstract

  • Petersen F B, Lynch M H, Clift R A, Appelbaum F R, Sanders J E, Bensinger W I, Benyunes M C, Doney K, Fefer A, Martin P, et al, Autologous marrow transplantation for patients with acute myeloid leukemia in untreated first relapse or in second complete remission., Journal of Clinical Oncology, 11(7):1353-60, July 1993 Abstract

  • Weaver C H, Appelbaum F R, Petersen F B, Clift R, Singer J, Press O, Bensinger W, Bianco J, Martin P, Anasetti C, et al, High-dose cyclophosphamide, carmustine, and etoposide followed by autologous bone marrow transplantation in patients with lymphoid malignancies who have received dose-limiting radiation therapy., Journal of Clinical Oncology, 11(7):1329-35, July 1993 Abstract

  • Bensinger W, Singer J, Appelbaum F, Lilleby K, Longin K, Rowley S, Clarke E, Clift R, Hansen J, Shields T, et al, Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte stimulating factor., Blood, 81(11):3158-63, 1 Jun 1993 Abstract

  • Bensinger W I, Price T H, Dale D C, Appelbaum F R, Clift R, Lilleby K, Williams B, Storb R, Thomas E D, Buckner C D, The effects of daily recombinant human granulocyte colony-stimulating factor administration on normal granulocyte donors undergoing leukapheresis [see comments], Blood, 81(7):1883-8, 1 Apr 1993 Abstract

  • Schiffman K, Clift R, Appelbaum F R, Sanders J, Bensinger W, Petersen F B, Rowley S, Hill R, Martin P, Storb R, et al, Consequences of cryopreserving first remission autologous marrow for use after relapse in patients with acute myeloid leukemia., Bone Marrow Transplantation, 11(3):227-32, March 1993 Abstract

  • Radich J P, Sanders J E, Buckner C D, Martin P J, Petersen F B, Bensinger W, McDonald G B, Mori M, Schoch G, Hansen J A, Second allogeneic marrow transplantation for patients with recurrent leukemia after initial transplant with total-body irradiation-containing regimens., Journal of Clinical Oncology, 11(2):304-13, February 1993 Abstract

  • Andrews R G, Bensinger W I, Knitter G H, Bartelmez S H, Longin K, Bernstein I D, Appelbaum F R, Zsebo K M, The ligand for c-kit, stem cell factor, stimulates the circulation of cells that engraft lethally irradiated baboons., Blood, 80(11):2715-20, 1 Dec 1992 Abstract

  • Clift R A, Buckner C D, Appelbaum F R, Schoch G, Petersen F B, Bensinger W I, Sanders J, Sullivan K M, Storb R, Singer J, et al, Allogeneic marrow transplantation during untreated first relapse of acute myeloid leukemia., Journal of Clinical Oncology, 10(11):1723-9, November 1992 Abstract

  • Andrews R G, Bryant E M, Bartelmez S H, Muirhead D Y, Knitter G H, Bensinger W, Strong D M, Bernstein I D, CD34+ marrow cells, devoid of T and B lymphocytes, reconstitute stable lymphopoiesis and myelopoiesis in lethally irradiated allogeneic baboons., Blood, 80(7):1693-701, 1 Oct 1992 Abstract

  • Bensinger W I, Buckner C D, Clift R A, Petersen F B, Bianco J A, Singer J W, Appelbaum F R, Dalton W, Beatty P, Fefer A, et al, Phase I study of busulfan and cyclophosphamide in preparation for allogeneic marrow transplant for patients with multiple myeloma., Journal of Clinical Oncology, 10(9):1492-7, September 1992 Abstract

  • Bensinger W I, Supportive care in marrow transplantation., Current Opinion In Oncology, 4(4):614-23, August 1992 Abstract

  • Storb R, Pepe M, Deeg H J, Anasetti C, Appelbaum F R, Bensinger W, Buckner C D, Cliff R A, Doney K, Hansen J, et al, Long-term follow-up of a controlled trial comparing a combination of methotrexate plus cyclosporine with cyclosporine alone for prophylaxis of graft-versus-host disease in patients administered HLA-id, Blood, 80(2):560-1, 15 Jul 1992 Abstract

  • Petersen F B, Buckner C D, Appelbaum F R, Sanders J E, Bensinger W I, Storb R, Deeg H J, Witherspoon R P, Sullivan K M, Clift R A, et al, Etoposide, cyclophosphamide and fractionated total body irradiation as a preparative regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study., Bone Marrow Transplantation, 10(1):83-8, July 1992 Abstract

  • Berenson R J, Bensinger W I, Kalamasz D F, Heimfeld S, Goffe R A, Berninger R W, Peterson D R, Thompson P, Strong D M, Transplantation of stem cells enriched by immunoadsorption., Progress In Clinical and Biological Research, 377, 449-57; discussion 4, 1992 Abstract

  • Petersen F B, Deeg H J, Buckner C D, Appelbaum F R, Storb R, Clift R A, Sanders J E, Bensinger W I, Witherspoon R P, Sullivan K M, et al, Marrow transplantation following escalating doses of fractionated total body irradiation and cyclophosphamide--a phase I trial., International Journal of Radiation Oncology, Biology, Physics, 23(5):1027-32, 1992 Abstract

  • Storb R, Longton G, Anasetti C, Appelbaum F R, Beatty P, Bensinger W, Crawford S, Deeg H J, Doney K, Fefer A, et al, Changing trends in marrow transplantation for aplastic anemia., Bone Marrow Transplantation, 10 Suppl 1, 45-52, 1992 Abstract

  • Sullivan K M, Mori M, Sanders J, Siadak M, Witherspoon R P, Anasetti C, Appelbaum F R, Bensinger W, Bowden R, Buckner C D, et al, Late complications of allogeneic and autologous marrow transplantation., Bone Marrow Transplantation, 10 Suppl 1, 127-34, 1992 Abstract

  • Storb R, Anasetti C, Appelbaum F, Bensinger W, Buckner C D, Clift R, Deeg H J, Doney K, Hansen J, Loughran T, et al, Marrow transplantation for severe aplastic anemia and thalassemia major., Seminars In Hematology, 28(3):235-9, July 1991 Abstract

  • Bensinger W I, Hadlock J, Slichter S J, Identification of alloimmunized patients: use of radiolabeled allogeneic platelet kinetic measurements and platelet antibody tests., Blood, 77(11):2372-8, 1 Jun 1991 Abstract

  • Doney K, Fisher L D, Appelbaum F R, Buckner C D, Storb R, Singer J, Fefer A, Anasetti C, Beatty P, Bensinger W, et al, Treatment of adult acute lymphoblastic leukemia with allogeneic bone marrow transplantation. Multivariate analysis of factors affecting acute graft-versus-host disease, relapse, and relapse-free survi, Bone Marrow Transplantation, 7(6):453-9, June 1991 Abstract

  • Berenson R J, Bensinger W I, Hill R S, Andrews R G, Garcia-Lopez J, Kalamasz D F, Still B J, Spitzer G, Buckner C D, Bernstein I D, et al, Engraftment after infusion of CD34+ marrow cells in patients with breast cancer or neuroblastoma., Blood, 77(8):1717-22, 15 Apr 1991 Abstract

  • Clift R A, Buckner C D, Appelbaum F R, Bryant E, Bearman S I, Petersen F B, Fisher L D, Anasetti C, Beatty P, Bensinger W I, et al, Allogeneic marrow transplantation in patients with chronic myeloid leukemia in the chronic phase: a randomized trial of two irradiation regimens., Blood, 77(8):1660-5, 15 Apr 1991 Abstract

  • Clift R A, Buckner C D, Appelbaum F R, Bearman S I, Petersen F B, Fisher L D, Anasetti C, Beatty P, Bensinger W I, Doney K, et al, Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens [see comments], Blood, 76(9):1867-71, 1 Nov 1990 Abstract

  • Petersen F B, Appelbaum F R, Hill R, Fisher L D, Bigelow C L, Sanders J E, Sullivan K M, Bensinger W I, Witherspoon R P, Storb R, et al, Autologous marrow transplantation for malignant lymphoma: a report of 101 cases from Seattle., Journal of Clinical Oncology, 8(4):638-47, April 1990 Abstract

  • Bensinger W I, Berenson R J, Peripheral blood and positive selection of marrow as a source of stem cells for transplantation., Progress In Clinical and Biological Research, 337, 93-8, 1990 Abstract

  • Berenson R J, Bensinger W I, Hill R, Andrews R G, Garcia-Lopez J, Kalamasz D F, Still B J, Buckner C D, Bernstein I D, Thomas E D, Stem cell selection--clinical experience., Progress In Clinical and Biological Research, 333, 403-10; discussion 4, 1990 Abstract

  • Bensinger W I, Berenson R J, Andrews R G, Kalamasz D F, Hill R S, Bernstein I D, Lopez J G, Buckner C D, Thomas E D, Positive selection of hematopoietic progenitors from marrow and peripheral blood for transplantation., Journal of Clinical Apheresis, 5(2):74-6, 1990 Abstract

  • Storb R, Deeg H J, Pepe M, Appelbaum F, Anasetti C, Beatty P, Bensinger W, Berenson R, Buckner C D, Clift R, et al, Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled tri, Blood, 73(6):1729-34, 1 May 1989 Abstract

  • Anasetti C, Amos D, Beatty P G, Appelbaum F R, Bensinger W, Buckner C D, Clift R, Doney K, Martin P J, Mickelson E, et al, Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma., New England Journal of Medicine, 320(4):197-204, 26 Jan 1989 Abstract

  • Hill R S, Mazza P, Amos D, Buckner C D, Appelbaum F R, Martin P, Still B J, Sica S, Berenson R, Bensinger W, et al, Engraftment in 86 with patients lymphoid malignancy after autologous marrow transplantation., Bone Marrow Transplantation, 4(1):69-74, January 1989 Abstract
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Last Updated: Jan 7 2003.

COS Expertise ID #135352
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Individual Expertise profile of William I. Bensinger, Copyright William I. Bensinger.
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Bone Marrow Transplantation
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